Cytology and Genetics5d ago
The Potential Impact of microRNA-Related Functional Polymorphisms in the Pathogenesis of Coronary Heart Disease - #microRNA #singlenucleotidepolymorphism #coronaryheartdisease #TaqManAssay #miRNA #SNP #CHD #rs2292832 #rs3746444 #rs11614913 #rs1044165 #rs767649 #MIR196A2 #MIR155 #MIR223 #MIR149 #genetics #medicine - https://link.springer.com/article/10.3103/S0095452725050093
The Potential Impact of microRNA-Related Functional Polymorphisms in the Pathogenesis of Coronary Heart Disease - Cytology and Genetics

Abstract MicroRNAs (miRNAs) are widely referred to as gene regulators for different diseases. Single nucleotide polymorphism (SNP) in miRNA genes affects miRNA transcription, maturation, target specificity, and interaction, contributing to coronary heart disease (CHD). This case-control study aimed to investigate the association of five miRNA SNPs—rs2292832, rs3746444, rs11614913, rs1044165, and rs767649—with CHD risk in the Pakistani population using the TaqMan assay. Among these, rs3746444 showed a significant association with CHD under co-dominant, dominant, heterozygous, and additive inheritance models. Similarly, rs11614913 was linked to CHD under co-dominant, dominant, recessive, and additive models. The SNP rs767649 was associated with CHD across co-dominant, dominant, recessive, heterozygous, and additive models. A strong association between rs1044165 and CHD was observed under the heterozygous model. Variants in MIR499A, MIR196A2, MIR155, and MIR223 emerged as significant genetic risk factors for CHD, whereas MIR149 did not show a meaningful association in this cohort. These findings suggest a potential role of miRNA polymorphisms in CHD pathogenesis; however, further studies with larger sample sizes are required to validate these associations.

SpringerLink
Andreas WiedenhoffOct 9
In #Grožnjan #Grisignana #Istria 🇭🇷 today. A place high up above the #Mirna river valley, views towards #Motovun included.
HusnainOct 6

RE: https://mastodon.social/@HafizHusnain/115328490796649616

This review connects molecular biology and clinical neuroscience, showing how #miRNAs could transform how we diagnose and treat neurodegenerative diseases.

Click Here to Access Full Article: https://rdcu.be/eJJJ3

#Neuroscience #Neurodegeneration #Biomarkers #miRNA #MolecularBiology #Alzheimers #Parkinsons #ALS #Huntingtons #biosensors #NGS #Diagnostics #Therapeutics #AcademicMastodon #OpenScience #springernature

HusnainOct 6

🧬 Latest review article published today!
“MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies — advances and challenges.”

Discover how miRNAs, tiny regulators of gene expression, are transforming diagnostics & therapies for Alzheimer’s, Parkinson’s, ALS & Huntington’s disease.

🔗 Read: https://doi.org/10.1007/s10072-025-08419-w

https://doi.org/10.3389/fnmol.2024.1386735

#Neuroscience #miRNA #Neurodegeneration #Biomarkers #MolecularBiology #AD

News BeepAug 2

Man in need of kidney transplant finds 1-in-100,000 match: His wife

For much of his adult life, Jim Irish was a self-proclaimed bachelor — moving cities every few years,…
#NewsBeep #News #Headlines #adultlife #doctor #englishteacher #fewyear #invasiveprocedure #jimirish #kidney #kidneytransplant #Latvia #LV #marriage #match #mirna #muchtime #need #vow #wife
https://www.newsbeep.com/34996/

Brigitte und Roland UnterwegsJun 17

Abschied von Porec und 2 Tage nach Triest

Nach einem wieder sehr guten Frühstück, im Monte Rosso, geht es wieder retour nach Trieste.

Wir wählen diesmal die Straßenroute und versuche am Meer entlang zufahren. Gleich vorweg, das gelingt nicht ganz gut, oft stehen wir oder müssen umdrehen, da wir uns verfahren. Navi haben wir zwar, aber mit dem Rad funktioniert es nicht ganz gut. Die ersten Kilometer geht es, es gibt einen […]

https://www.brigitteundrolandunterwegs.com/b/7w3

#AlpeAdriaRadweg #Antenal #Apartment #Arnoldstein #BarTropicana #Dalja #Fahrradgepäck #Fähre #Genusstour #Grenzübertritt #Hafen #Izola #Koper #Leibnitz #Mirna #Monterol #Muggia #Novigrad #Ortlieb #Porec #Portorož #RadlDilemma #Radweg #Salinen #slowenien #Straßenroute #trieste #Umag #Valica #Vižinada #Zugfahrt

Amelia Cervera 🧬Mar 30

Circular RNAs derived from MIR156D promote rice heading by repressing transcription elongation of pri-miR156d through R-loop formation.

#RNA #miRNA #circRNA #Rloop #Oryza_sativa #PlantScience

https://www.nature.com/articles/s41477-025-01961-7

Circular RNAs derived from MIR156D promote rice heading by repressing transcription elongation of pri-miR156d through R-loop formation - Nature Plants

This study uncovers a mechanism of rice heading regulation mediated by circular RNAs (ciMIR156Ds) derived from pri-miR156d that refine the aging-dependent expression of miR156 through R-loop formation.

Nature
datum (n=1)Mar 2

TLDR: Pandas are dope fiends!?

TIL that 🐼 Pandas aren't born loving 🎍bamboo, but that it's an addiction with a dopamine component.

Those cute furry pandas are actually carnivores. 🍖

But they sit on their butts all day eating plants 🌿 and getting 🌀👃🌀 high instead of chasing animals. 🐁

Quote: "some of the bamboo-derived miRNAs were found to regulate dopamine pathways, driving food motivation and the reward system linked to it. So if eating bamboo is a pleasurable, satisfying experience for a panda, it's more likely to be solely driven to seek out this trigger." https://newatlas.com/biology/pandas-bamboo-micro-rna/

Pandas!   

#drugs #dopamine #pandas #bamboo #miRNA #RNA

Pandas "tricked" into becoming the world's biggest bamboo fans

Built to be carnivorous, giant pandas spend up to 16 hours a day on their backsides eating bamboo. But contrary to all the panda jokes, it's not because they're lazy or too dumb to know better. It's far more fascinating – and it may help humans, too.

New Atlas
CellBioNewsFeb 28

Why don't #pandas eat more meat? #Molecules found in #bamboo may be behind their plant-based diet.

#miRNA #regulation #gene_expression #sensing #dopamine

https://phys.org/news/2025-02-dont-pandas-meat-molecules-bamboo.html

Why don't pandas eat more meat? Molecules found in bamboo may be behind their plant-based diet

Giant pandas have digestive systems that are typical for carnivores. Yet, bamboo is their main source of food. They have evolved several features; for example, pseudo thumbs to grasp bamboo and flat teeth that are well suited for crushing it, that make it possible for them to live off plants.

Phys.org
Victoria Stuart 🇨🇦 🏳️‍⚧️Feb 19

The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers
https://www.science.org/doi/10.1126/sciadv.ado2830
pdf: https://www.science.org/doi/epdf/10.1126/sciadv.ado2830

* diverse regulatory roles in cancer

#cancer #genetics #genomics #FunctionalGenomics #NoncodingDNA #ncDNA #miRNA #GeneRegulation #CRISPR