Researchers seem to be closer to pinpointing the causes of essential tremor. This recent (2024) huge genome-wide association study https://www.nature.com/articles/s42003-024-06207-4 implicates CA3 and CPLX1, supports GABA dysregulation theories, and highlights differences in Rho GTPase cycle.

Since Rho GTPases are involved in axon "growth, guidance, and branching" https://pmc.ncbi.nlm.nih.gov/articles/PMC2828272/, the last point helps explain the pathophysiology in ET: degeneration and swelling (formation of "torpedoes") of the axons, and dendrite loss/reduction in complexity of branching https://pmc.ncbi.nlm.nih.gov/articles/PMC10461794/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4240305/

Axon guidance processes were also implicated in this 2019 RNA-seq and GSEA study https://pmc.ncbi.nlm.nih.gov/articles/PMC7593093/, along with "microtubule motor activity," "endoplasmic reticulum (ER) to Golgi transport" and "calcium signaling/synaptic transmission."

Both the big GWAS study and this preprint published around the same time last year https://www.biorxiv.org/content/10.1101/2024.05.22.595233v1 found an association with BACE2, but the latter explains how that brings oligodendrocytes into the picture. The Rho GTPase PMC paper above has a section called "Other Guidance Cues" that describes how oligodendrocytes are involved in axon guidance.

This is clearly a complex network of processes, and that might explain why ET has so many different inheritance patterns: studies of smaller groups of related people often show different significant genes. Different changes at different key nodes in the network can cause similar cascading failures. Also, the common pathways might help explain what's happening in acquired ET, where pathology can be induced by things like lead and harmane https://pmc.ncbi.nlm.nih.gov/articles/PMC3073713/ (and other papers from the Elan Louis lab https://labs.utsouthwestern.edu/louis-lab/research#230548828-2207731419)

#EssentialTremor #Tremor #Etiology #Pathology #Pathophysiology #Neuroscience #Neurology

I’ve been infected with SARS-CoV-2 once I know of from June 2022 on:
the cause of the long covid that now defines my daily existence.
I suspect once more in March or April 2020 — but of fucking course, at that time the public could not access covid tests!

Every ignorant person who asserts they’ve never had it
could have been ASYMPTOMATIC
(that they noticed / wanted to notice / were in a position to consider it amid whatever went on in their lives at the time).

Absolutely no one can say they were never infected unless they were a
complete 24/7 no-cheat hermit
and / or covid testing
correctly at least once daily, *every single morning* from November 2020 to now.

And guess what else?
The (rapid lateral flow) antigen tests probably haven’t been updated to the latest strains in a while.

Good luck if you do have Covid 19 but can’t get time off work!
The (possibly expired) disposable test may not pick up new strains as reliably as older ones, which won’t be circulating as much as newer ones.

#covid #covid19 #pandemic #lockdown #LongCovidKids #longCovid #longHaulers #cardiovascular #CVD #heart #heartDisease #pulmonary #heartAttack #myocardialinfarction #etiology #transmission #infection #disease #CDC #NHS

I don’t want to nag or harp on about it, but if anyone, by choice, unvaccinated and / or non masking and / or not using air filtration feels comfortable sharing,
would you be able to articulate exact discomforts with Covid vaccination, respirators, and air filtration?

I would like to collect relevant information into a layperson’s FAQ on covid prevention.

You don’t have to share, and even if you want to, I don’t need to mention you at all.

I just want to make something a bit more approachable than https://www.youtube.com/watch?v=Va0RCgbywGc cuz 45 min is a lot to ask of anyone not already interested in the topic and / or presenter tbh.

(Like, I’ll assume no one wants to be identified as a matter of course, tbh.)

#antivax #vaccine #vaccination #etiology idk maybe not. Am I sticking my nose where it doesn’t belong? Would I cause more harm than good? Hm.

...But, is that enough? Even two men sharing their thoughts will soon include the third. Two tribes will form a city. States will form based on mutual respect and balance of power despite the differences. Another tower in another Shinar will be built…

#etiology #myth #biblical #musing #digitalgarden

https://hermitage.utsob.me/musings/the-tower-of-babel/

Epic Poems that portray a series of heroes involved in the foundations of civilizations:

Mahabharata for India
Shahnameh for Persia
The Faerie Queene for Britain
Hermead for Academia

http://tinyurl.com/HermeadEpic

#Epic #Civilization #Etiology #FoundingMyth #Academia