What is prothrombin time (PTT)?

Prothrombin time is taken on a plasma sample to determine its coagulation (exogenously).

Prothrombin time is measured for the following purposes:

determining the hemorrhagic tendency associated with deficiency of coagulation factors type II, V, VII or X, monitoring anticoagulant treatment using antivitamins K, determining liver disorders associated with vitamin K deficiency.

#prothrombin #plasma #antivitamin #coagulation

2️⃣ Adriani highlights a study that explores targeting Factor XI to prevent dangerous clots like DVT and pulmonary embolism—avoiding the bleeding risks of current treatments. #preprint from the Yamashita Lab.

#preLight: https://prelights.biologists.com/highlights/factor-xi-localization-in-human-deep-venous-thrombus-and-function-of-activated-factor-xi-on-venous-thrombus-formation-and-hemostasis-in-rabbit/

#biochemistry #medicine #coagulation #hemostasis #pathology #VTE

Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit - preLights

Could blood thinners be made safer? This study explores targeting Factor XI to prevent dangerous clots like DVT and pulmonary embolism—avoiding the bleeding risks of current treatments

preLights

research article from 2011:

N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice
https://www.jci.org/articles/view/41062

#NAC #vonWillebrandFactor
#clotting #coagulation #thrombosis

JCI - N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

The building blocks of new #planets could form more easily than previously thought.

Some studies have suggested that #dust grains are not so sticky, and that their growth may be limited by fragmentation in #planet-forming regions because of high collision velocities.

But new results demonstrate that clumping and #coagulation processes help each other to proceed quickly, acting as a positive-feedback loop.

https://phys.org/news/2024-02-growth-planets-easily-previously-thought.html

Paper by Ryosuke & Tanaka (2024):
https://iopscience.iop.org/article/10.3847/1538-4357/ad002e

Dust growth model finds planets may form more easily than previously thought

The building blocks of new planets could form more easily than previously thought, according to calculations by a team led by a RIKEN astrophysicist.

Phys.org
Yesterday & Today #History: 1922 The #Federation of #American Societies for #Experimental #Biology advanced understanding of #tissue fibrinogen (blood clotting) following the work of #German physiologist Paul Morawitz in #studying the #coagulation of blood. Today blood-thinning #medications are used to #prevent blood #clots & electrocauterization (electricity used to heat & seal tissues) or ligation (tying off blood vessels).

@ahather I've got a vague recollection that there's stuff in saliva that is good for minor cuts. That's why there's an impulse to lick them.

I think it's to do with #coagulation science, but it's a few decades since I did any of that seriously