3D-printed carotid artery-on-chips for personalized thrombosis investigation

https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202508890

#HackerNews #3Dprinting #personalizedmedicine #thrombosis #biomaterials #healthtech

#Covid causes what we in the biz call "#cardiovascular events," among its other nasty effects. #Heart attack, #stroke, pulmonary #embolism, deep vein #thrombosis. All things you should try to avoid.

https://www.nature.com/articles/s41467-024-49634-x

The covid #vaccine—any of the currently approved vaccines—helps protect against such events. A #mechanism isn't yet clear: the obvious hypothesis is that it works by reducing the incidence and sincerity of covid, and therefore reduces the effects of the disease. Say it with me now: further research is needed. Send me a pile of cash and I'll be happy to get on that, BTW.

(It also helps protect against #cancer, by an entirely different mechanism. I can natter about that if anyone wants.)

But the effect itself is clear. Has been from the start of the #mRNA vaccine era, really. Now a very large-scale study has confirmed it. There will be more studies, as there should be. They will show the same result. I'd bet my fortune on that, if I had a fortune, because then I'd have an even bigger fortune. Have I mentioned lately that #scientists need to eat?

As it is, all I have to pledge is my life and my sacred honor. I take both of those pretty seriously.

Of course this runs directly counter to the #antivax narrative. Based on a transitory and maybe illusory increase in clotting risk from an early vaccine that's no longer on the market (Johnson & Johnson) they've built an entire mythology about "the #clot shot." Lately they've added "#turbo cancer," which is not a thing that exists, to the canon.

So when dedicated antivaxers see any of the large and ever-growing number of studies showing protective effects against more than the #infection itself, especially against the exact same problems they claim the vaccine causes, they react with mockery and/or rage. It's all they know how to do.

Years of bitter experience have taught me there's no point in trying to reason with them. I still hold out hope that at least some antivax sentiment isn't that dedicated, that a lot of people are scared of getting vaccinated out of the general unease brought on by ignorance.

Oh yeah: the Methods section in the linked article provides details on data collection and analysis. It looks good to me, and I have a whole lot of experience in study design. Note that no vaccine manufacturers provided #funding. For a full list of funding sources, see the Acknowledgements.

I don't suppose I have many if any antivaxers left in my audience. If I do, well, I guess there's a reason you're still here. And if you like me or trust me or respect me at all, please pay attention to my words.

For everyone else, if what I've written here is useful, please do with it what you can.

“Who am I to stop taking my medication?"

Patient Perspectives on Antithrombotic Therapy in Advanced Cancer

#cancer #thrombosis #geriatrics #medmastodon #medication #sdm #palliative

https://oncodaily.com/voices/simon-mooijaart355762

🥳 Superproud of this bunch: the management team of the CoClarity #RCT. Submitted the trial protocol today.

CoClarity: A Shared Decision Support Tool to reconsider the use of Anti-Thrombotic Therapy in patients with #cancer in the last phase of life

✅ Lower risk of #thrombosis
🛑 Higher risk of bleeding
❓ When to stop?

#SDM #geriatrics #deprescribing #medmastodon