Show threadpreLightsJan 7, 2025

2️⃣ Adriani highlights a study that explores targeting Factor XI to prevent dangerous clots like DVT and pulmonary embolism—avoiding the bleeding risks of current treatments. #preprint from the Yamashita Lab.

#preLight: https://prelights.biologists.com/highlights/factor-xi-localization-in-human-deep-venous-thrombus-and-function-of-activated-factor-xi-on-venous-thrombus-formation-and-hemostasis-in-rabbit/

#biochemistry #medicine #coagulation #hemostasis #pathology #VTE

Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit - preLights

Could blood thinners be made safer? This study explores targeting Factor XI to prevent dangerous clots like DVT and pulmonary embolism—avoiding the bleeding risks of current treatments

preLights
RhyothemisAug 26, 2024

FDA Clears Gel-Based Device That Instantly Stops Severe Bleeding: What To Know About Traumagel

https://www.forbes.com/sites/ariannajohnson/2024/08/15/fda-clears-gel-based-device-that-instantly-stops-severe-bleeding-what-to-know-about-traumagel/

The article is full of popups, but it's informative since it explains that this is a medical device, so it received FDA clearance - not FDA approval as for Rx drugs.

The main ingredients are apparently sodium alginate and chitosan*. I tried to find a full ingredient list since I would like to know if there are any corn ingredients or other allergens, but was unable to find it.

* https://patents.google.com/patent/WO2016209198A1/en

News video shows what it looks like (hummus) -
https://www.youtube.com/watch?v=yxeH-dZncTc

I'm guessing Landolina was using a sodium alginate GERD product when he got his idea. I tried one for GERD - did not seem to do much for me.

#medicine #TraumaMedicine #EmergencyMedicine #WoundCare #hemostasis
#NaturalProducts

FDA Clears Gel-Based Device That Instantly Stops Severe Bleeding: What To Know About Traumagel

Traumagel is inserted through a syringe into severe injuries like bullet wounds, and instantly stops bleeding by helping the patient form their own blood clots.

Forbes
Michiel De SmetJul 8, 2023
📚 Keeping Up with the Evidence 📚
The field of TXA in resuscitation is evolving rapidly. Ongoing research continues to refine our understanding of its optimal use, dosing strategies, and potential applications in various clinical contexts. Staying updated with the latest evidence is vital for healthcare professionals involved in resuscitation efforts.
#TranexamicAcid #Resuscitation #Hemostasis (7/7)
Michiel De SmetJul 8, 2023
🌟 The Power of Timing: Early Administration 🌟
In the realm of TXA administration, timing is crucial. Research consistently highlights the importance of early initiation of TXA to maximize its benefits. The sooner it is administered after the onset of bleeding, the greater the potential for improved outcomes.
#TranexamicAcid #Resuscitation #Hemostasis (6/7)
Michiel De SmetJul 8, 2023
🚑 Expanding the Application: Beyond Trauma 🚑
While TXA initially gained prominence in trauma resuscitation, its potential benefits are being explored in other critical care settings. From postpartum hemorrhage to gastrointestinal bleeding and even intracerebral hemorrhage, studies are investigating TXA's effectiveness in diverse scenarios.
#TranexamicAcid #Resuscitation #Hemostasis (5/7)
Michiel De SmetJul 8, 2023
🔍 The CRASH-2 Trial: A Resounding Revelation 🔍
The landmark CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) trial paved the way for the use of TXA in resuscitation. This large-scale study involving over 20,000 trauma patients demonstrated that early administration of TXA significantly reduced mortality due to bleeding.
#TranexamicAcid #Resuscitation #Hemostasis (4/7)
Michiel De SmetJul 8, 2023
🌪️ The Storm of Traumatic Hemorrhage 🌪️
Traumatic hemorrhage remains a leading cause of preventable death worldwide. In critical situations where severe bleeding jeopardizes a patient's life, prompt and effective hemostatic interventions are essential. This is where TXA steps in.
#TranexamicAcid #Resuscitation #Hemostasis (3/7)
Michiel De SmetJul 8, 2023
💊 Understanding Tranexamic Acid 💊
TXA is an antifibrinolytic medication that works by preventing the breakdown of blood clots. It helps stabilize clot formation and reduces bleeding in various clinical scenarios. Originally used in surgical and trauma settings, TXA's potential benefits in resuscitation have sparked widespread interest and research.
#TranexamicAcid #Resuscitation #Hemostasis (2/7)
Michiel De SmetJul 8, 2023
🩸 Tranexamic Acid 🩸
When it comes to resuscitation efforts, every tool that can potentially save a life is worth exploring. One such tool that has emerged as a game-changer is tranexamic acid (TXA). Today, let's delve into the use of TXA in resuscitation and its significant impact on patient outcomes.
#TranexamicAcid #Resuscitation #Hemostasis (1/7)
Scientific FrontlineMar 24, 2023
The #platelet #glycoprotein V is an important switching point for #hemostasis and #thrombus formation. This new finding could have great clinical potential.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/03/med03242302.html
Revolutionary discovery for blood clotting

Treatment with soluble GPV prevents the formation of a vascular-closing thrombus