Mathrubhumi EnglishNov 22
Kerala-based private banks will soon launch the Capital Gains Accounts Scheme, enabling customers to claim tax exemption by depositing profits from property sales until a new home is bought or built. A major shift, as the facility was earlier limited to public sector banks. https://english.mathrubhumi.com/news/kerala/want-to-save-capital-gains-tax-on-property-sales-kerala-based-private-banks-offer-new-option-q64c6a12?utm_source=dlvr.it&utm_medium=mastodon #KeralaBanks #CapitalGainsTax #CGAS #FinanceNews #IndianBanking
Nonia ParienteDec 11, 2023

#CoolPaper alert 📢📢
So pleased that this is out in published form
@PLOSBiology

The #evolutionary #origins of eukaryotic innate #immune systems have firmly crossed prokaryotic divide. Their study is fascinating, provides really interesting insights & avenues of future discovery

Ed Culbertson & Tera Levin reveal origins of 3 families of #antiviral proteins: CD-NTases (incl #cGAS), #STINGs & #Viperins; each connecting #animal & #bacterial immunity

https://plos.io/46SfBqM

Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes

How and when did our innate immune systems first evolve? This study analyses diverse eukaryotes, uncovering the evolutionary origins of three families of antiviral proteins: CD-NTases (including cGAS), STINGs and Viperins; each reveals a different story connecting animal and bacterial immunity.

PLOS BiologyDec 11, 2023
How did our #InnateImmune systems first evolve? Ed Culbertson & @tera_levin reveal origins of three families of #antiviral proteins: CD-NTases (incl #cGAS), STINGs & #Viperins; each reveals a different story connecting animal & bacterial immunity #PLOSBiology https://plos.io/46SfBqM
Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes

How and when did our innate immune systems first evolve? This study analyses diverse eukaryotes, uncovering the evolutionary origins of three families of antiviral proteins: CD-NTases (including cGAS), STINGs and Viperins; each reveals a different story connecting animal and bacterial immunity.

CellBioNewsNov 16, 2023

How #bacteria recognize #viral invasion and activate #immune defenses.

#CBASS #cGAS #CRISPR

https://phys.org/news/2023-11-bacteria-viral-invasion-immune-defenses.html

How bacteria recognize viral invasion and activate immune defenses

There's no organism on Earth that lives free of threat—including bacteria. Predatory viruses known as phages are among their most dire foes, infiltrating their cells to replicate and take over. Bacteria have evolved an array of strategies to counter these infections, but how they first spot an invader in their midst has long been a mystery.

Phys.org
The EMBO JournalApr 17, 2023

Issue 8:
Review on RNA-mediated #heterochromatin formation in our RNA focus series

Highlight on common adaptive strategies to differently induced chromosomal instability #CIN

#cGAS/STING DNA sensing activating #immunoproteasomes

#Epigenetic reprogramming in plant shade responses

Cover: Yoo Lab, RIKEN

https://www.embopress.org/toc/14602075/2023/42/8

The EMBO JournalMar 20, 2023

DNA sensing via the #cGAS/STING pathway regulates #immunoproteasome function and #MHC class I #antigen presentation to promote #Tcell activation - with implications for the pathology of idiopathic pulmonary fibrosis

Silke Meiners et al [email protected]

https://www.embopress.org/doi/10.15252/embj.2022110597

The EMBO JournalMar 7, 2023

STING directly recruits #WIPI2 for #autophagosome formation during STING-induced #autophagy - autophagy-dependent clearance of cytoplasmic DNA attenuating #cGAS-STING signaling.

https://www.embopress.org/doi/10.15252/embj.2022112387

CellBioNewsMar 1, 2023

Researchers report new mechanism in an ancient pathway of #immune response.

#cGAS #signaling

https://phys.org/news/2023-03-mechanism-ancient-pathway-immune-response.html

Researchers report new mechanism in an ancient pathway of immune response

UT Southwestern biochemist Zhijian "James" Chen, Ph.D., famously identified the cGAS enzyme pathway that alerts the human immune system to disease-causing invaders like viruses. Since then, researchers have found that cGAS signaling is an ancient, conserved defense strategy stretching from bacteria to mammals. A new study from the Chen lab published in Nature reports a novel mechanism bacteria use to enhance the effectiveness of the cGAS-mediated immune response.

The EMBO JournalJan 5, 2023
#DNAdamage #DNArepair #kinase #DNAPK and #cGAS synergize to induce cancer-related #inflammation in #glioblastoma
Clara Taffoni, Johanna Marines, Nadine Laguette et al at IGH Montpellier
https://www.embopress.org/doi/10.15252/embj.2022111961
Sarah MelamedDec 22, 2022

R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response

https://www.nature.com/articles/s41586-022-05545-9
#immuneresponse #immunesystem #dna #rna #rooms #cytoplasma #cgas

R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response - Nature

RNA–DNA hybrids are immunogenic species that can aberrantly accumulate in the cytoplasm after R-loop processing, linking R-loop accumulation to cell death through the innate immune response.

Nature