Nonia Pariente#CoolPaper alert π’π’
So pleased that this is out in published form
@PLOSBiology
The #evolutionary #origins of eukaryotic innate #immune systems have firmly crossed prokaryotic divide. Their study is fascinating, provides really interesting insights & avenues of future discovery
Ed Culbertson & Tera Levin reveal origins of 3 families of #antiviral proteins: CD-NTases (incl #cGAS), #STINGs & #Viperins; each connecting #animal & #bacterial immunity
Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes
How and when did our innate immune systems first evolve? This study analyses diverse eukaryotes, uncovering the evolutionary origins of three families of antiviral proteins: CD-NTases (including cGAS), STINGs and Viperins; each reveals a different story connecting animal and bacterial immunity.
Kelvin Lau