Innate immune signaling and
#cancer: This study shows that the tissue-protective functions of Toll-mediated
#InnateImmune signaling can be misused by premalignant cells in
#Drosophila to induce overgrowth in early stages of
#tumor development
@PLOSBiology https://plos.io/4jqpmUh
Activation of the Drosophila innate immune system accelerates growth in cooperation with oncogenic Ras
Innate immune signaling acts as a surveillance system to fight potential infections, but it can become overactivated in malignant cells. These authors show that the tissue-protective functions of innate immune signaling involving oncogenic Ras can be misused by premalignant cells in Drosophila to induce overgrowth in the initial stages of tumor development.
#ProteinQC pathways play key roles in resistance to
#pathogens. @manishgrover_4 @barkoulab &co show that
#proteasome regulation keeps
#InnateImmune responses against natural pathogens of
#Celegans in check in a tissue-specific manner
#PLOSBiology https://plos.io/3PhIjLW 
Proteasome inhibition triggers tissue-specific immune responses against different pathogens in C. elegans
Protein quality control pathways play important roles in resistance against pathogen infection. This study shows that proteasome regulation keeps innate immune responses in check in a tissue-specific manner, against natural eukaryotic pathogens of the C. elegans epidermis and intestine.
How did our
#InnateImmune systems first evolve? Ed Culbertson & @tera_levin reveal origins of three families of
#antiviral proteins: CD-NTases (incl
#cGAS), STINGs &
#Viperins; each reveals a different story connecting animal & bacterial immunity
#PLOSBiology https://plos.io/46SfBqM
Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes
How and when did our innate immune systems first evolve? This study analyses diverse eukaryotes, uncovering the evolutionary origins of three families of antiviral proteins: CD-NTases (including cGAS), STINGs and Viperins; each reveals a different story connecting animal and bacterial immunity.
The
#GPCR CMKLR1 responds to the
#adipokine #chemerin and is abundant in
#InnateImmune cells. Structure of CMKLR1 in complex with
#Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action
#PLOSBiology https://plos.io/4a6Igvd
Structural basis of G protein–Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist
Chemokine-like receptor 1 (CMKLR1) responds to the adipokine chemerin and is highly expressed in innate immune cells. A high-resolution structure of CMKLR1 in complex with G protein and a peptide agonist, together with mutagenesis and computational simulations studies, reveals mechanisms of peptide agonist recognition, receptor activation, and G protein-coupling.
Seung Kim, Frederick Dick et al show that resting #Bcells are uniquely sensitive to #EZH2 #polycomb complex inhibition, which activates expression of repetitive genomic elements and subsequent #innateimmune receptor signaling in a form of viral mimicry
https://www.embopress.org/doi/full/10.15252/embj.2023114462
MICa/b-dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to #autoimmunity
Pathology of primary Sjögren's syndrome is known to involve #interferons, but Enrique Martin-Gayo et al @UAM_Medicina show additional roles also for #innateimmune cells like natural killer and #dendritic cells
https://www.embopress.org/doi/full/10.15252/embj.2023113714
The past 20 years have revealed several new
#InnateImmune sensing &
#CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential
#PLOSBiology https://plos.io/40O9xxQ
Innate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications
The past 20 years of research has revealed several new innate immune sensing and cell death pathways with disease relevance. This Perspective looks back over the impact these discoveries have had and forwards toward their future therapeutic potential.
The past 20 years have revealed several new
#InnateImmune sensing &
#CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential
#PLOSBiology https://plos.io/40O9xxQInnate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications
The past 20 years of research has revealed several new innate immune sensing and cell death pathways with disease relevance. This Perspective looks back over the impact these discoveries have had and forwards toward their future therapeutic potential.
The past 20 years have revealed several new
#InnateImmune sensing &
#CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential
#PLOSBiology https://plos.io/40O9xxQInnate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications
The past 20 years of research has revealed several new innate immune sensing and cell death pathways with disease relevance. This Perspective looks back over the impact these discoveries have had and forwards toward their future therapeutic potential.
PLOS Biology
The EMBO Journal
