CellBioNewsAug 22, 2024

Ancient #microbes linked to #evolution of human #immune #proteins.

#Asgard #archaea #viperins #argonautes #eukaryotes

https://phys.org/news/2024-08-ancient-microbes-linked-evolution-human.html

Ancient microbes linked to evolution of human immune proteins

When you become infected with a virus, some of the first weapons your body deploys to fight it are those passed down to us from our microbial ancestors billions of years ago. According to new research from The University of Texas at Austin, two key elements of our innate immune system came from a group of microbes called Asgard archaea.

Phys.org
Nonia ParienteDec 11, 2023

#CoolPaper alert πŸ“’πŸ“’
So pleased that this is out in published form
@PLOSBiology

The #evolutionary #origins of eukaryotic innate #immune systems have firmly crossed prokaryotic divide. Their study is fascinating, provides really interesting insights & avenues of future discovery

Ed Culbertson & Tera Levin reveal origins of 3 families of #antiviral proteins: CD-NTases (incl #cGAS), #STINGs & #Viperins; each connecting #animal & #bacterial immunity

https://plos.io/46SfBqM

Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes

How and when did our innate immune systems first evolve? This study analyses diverse eukaryotes, uncovering the evolutionary origins of three families of antiviral proteins: CD-NTases (including cGAS), STINGs and Viperins; each reveals a different story connecting animal and bacterial immunity.

PLOS BiologyDec 11, 2023
How did our #InnateImmune systems first evolve? Ed Culbertson & @tera_levin reveal origins of three families of #antiviral proteins: CD-NTases (incl #cGAS), STINGs & #Viperins; each reveals a different story connecting animal & bacterial immunity #PLOSBiology https://plos.io/46SfBqM
Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes

How and when did our innate immune systems first evolve? This study analyses diverse eukaryotes, uncovering the evolutionary origins of three families of antiviral proteins: CD-NTases (including cGAS), STINGs and Viperins; each reveals a different story connecting animal and bacterial immunity.