Mastodawn

Sicilianews24.it: Mastectomia radicale vs. mastectomia radicale modificata: le principali differenze

La mastectomia è un intervento chirurgico che prevede la rimozione di uno o entrambi i seni. Questa procedura può essere necessaria per vari motivi, che analizzeremo di seguito, tenendo conto delle diverse esigenze che possono portare a questa decisione.
Motivi per cui è necessaria la mastectomia
Uno dei principali motivi per cui si ricorre alla mastectomia è la presenza di un tumore al seno. Infatti, questa operazione rappresenta una delle terapie più comuni per il carcinoma mammario. La diagnosi precoce e l’intervento tempestivo possono fare la differenza nella prognosi e nel recupero della paziente.
Un secondo motivo è rappresentato dalla prevenzione. Le donne che presentano un elevato rischio di sviluppare tumore al seno, per esempio a causa di fattori genetici come la mutazione dei geni BRCA1 o BRCA2, potrebbero optare per una mastectomia preventiva. Questa scelta è spesso discutibile e richiede un colloquio approfondito con specialisti del settore.
Interventi di riassegnazione di genere e altre condizioni

L'articolo Mastectomia radicale vs. mastectomia radicale modificata: le principali differenze sembra essere il primo su Sicilianews24.it.

Radical mastectomy vs. modified radical mastectomy: the main differences

Mastectomy is a surgical procedure that involves the removal of one or both breasts. This procedure may be necessary for various reasons, which we will analyze below, taking into account the different needs that may lead to this decision.

Reasons for Mastectomy

One of the main reasons for resorting to mastectomy is the presence of a breast tumor. Indeed, this operation represents one of the most common therapies for breast cancer. Early diagnosis and timely intervention can make a difference in the patient’s prognosis and recovery.

A second reason is represented by prevention. Women who are at high risk of developing breast cancer, for example due to genetic factors such as the mutation of genes BRCA1 or BRCA2, may opt for a preventative mastectomy. This choice is often debated and requires a thorough consultation with specialists in the field.

Gender reassignment procedures and other conditions

The article “Radical Mastectomy vs. Modified Radical Mastectomy: the main differences” appears to be the first on Sicilianews24.it.

#second #BRCA1 #BRCA2 #first

https://www.sicilianews24.it/mastectomia-radicale-vs-mastectomia-radicale-modificata-le-principali-differenze-828122.html

Mastectomia radicale vs. mastectomia radicale modificata: le principali differenze

La mastectomia è un intervento chirurgico che prevede la rimozione di uno o entrambi i seni. Questa procedura può essere necessaria per vari motivi, che

Sicilianews24.it

Cytology and Genetics Apr 21

Genetically Significant Hereditary Mutations Associated with Breast and Ovarian Cancer among Ukrainian Women - #breastcancer #ovariancancer #hereditarymutation #BRCA1 #BRCA2 #CHEK2 #Ukraine #cancer #genetics #mutations - https://link.springer.com/article/10.3103/S009545272601007X

Genetically Significant Hereditary Mutations Associated with Breast and Ovarian Cancer among Ukrainian Women - Cytology and Genetics

Abstract The study of mutations associated with the syndrome of hereditary breast cancer (BC) and ovarian cancer (OC) is extremely important for understanding the genetic risks among Ukrainian women. In this work, we conducted NGS study of mutations in the genes associated with the syndrome of hereditary BC and OC in 1090 women who had indications for testing and 407 women from the control group. As a result of the study, 233 patients with mutations were identified, including 84 unique variants. The largest number of mutations was registered in the BRCA1 (102), BRCA2 (42), and CHEK2 (67) genes. In the BRCA1 gene, the following mutations were the most frequent: c.5266dup (p.Gln1756fs), 45 cases; c.181T>G (p.Cys61Gly), 13; c.1510del (p.Arg504fs), 6; c.4035del (p.Glu1346fs), 5. The BRCA1 gene is a key risk factor for the development of cancer at a young age, while the CHEK2 is more frequently associated with cancer at an older age. The Population Attributable Risk (PAR) for the BRCA1 is 7.49%, which makes this gene a major risk factor. The odds ratio for mutations in the CHEK2 is 1.84 (95% CI: 1.01–3.34), while the PAR is 2.2%. The highest frequency of mutations (BRCA1 and BRCA2) was registered in the Central region of Ukraine. We for the first time performed a large-scale genetic study of the prevalence of hereditary mutations associated with the syndrome of hereditary BC and OC in Ukraine, the frequency of the most common mutations in the studied and control cohorts were determined.

SpringerLink

Benjamin Carr, Ph.D. 👨🏻‍💻🧬Mar 13

#GumDisease bacteria can promote #cancer growth in mice
Human #breastcancer cells with a #BRCA1 mutation could be more susceptible to damage, lab experiments suggest
The work suggests that harmful bacteria in the mouth may enter the bloodstream, make a beeline for breast tissue and then whomp healthy cells like a wrecking ball. Previous studies have turned up correlations between oral disease and breast cancer, but “now we have a direct connection”
https://www.sciencenews.org/article/gum-disease-bacteria-breast-cancer
https://archive.ph/XZLwp

Gum disease bacteria can promote cancer growth in mice

In mice, the oral bacteria F. nucleatum can travel to mammary tissue via the bloodstream, where it can damage healthy cells.

Science News

Mapi_María Pilar Menoyo Díaz Jun 13, 2025

#13Junio ☕ con buenas noticias vía @elpais.com "Premio Princesa de Asturias de Ciencia a #Mary_ClaireKing y su genética del #cáncer" "El #ADN mitocondrial era un rastro invisible que desbarató el plan de los represores" #AbuelasdelaPlazadeMayo #cáncerdemama #BRCA1 #BRCA2

John Vaccaro (johniac)Mar 8, 2025

SciTech Chronicles. . . . . . . . .Mar 8th, 2025

https://bit.ly/stc030825

#BRCA1 #BRCA2 #PARPi #cytotoxicity #Basra #Mesopotamia #irrigation #Euphrates #diabetes #gut #beta-cells #C.dubliniensis #ionosphere #thermosphere # Meridian-Project #TIEGCM #kelps #micronutrients #biosorption #phytomining

SciTech Chronicles. . . . . . . . .Mar 8th, 2025

From the lab to the street,trust in science not deceit.. Vol II No 61 299 links Curated Scientists upends understanding of how anticancer ...

LifeCode Genomics Mar 3, 2025

BRCA Testing for Breast Cancer and Ovarian Cancer

#genetic #genetictesting #brcatesting #brcatestingcost #brca1 #brca2 #cancer #breastcancer #healthcare #cancer

BRCA Testing Cost | BRCA Gene Testing Cost

Explore the BRCA Testing Cost, BRCA Gene Testing Cost, BRCA 1 and 2 Testing Cost, and BRCA Testing Cost in India.

Scientific Frontline Mar 29, 2024

Everyone has #BRCA1 and #BRCA2 genes, but mutations in these #genes - which can be inherited - increase the risk of #breast and #ovarian #cancer
#Genetics #Biology #Medical #sflorg
https://www.sflorg.com/2024/03/gen03292401.html

‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention

We’re very excited about this discovery, because it opens up potential for a preventative treatment other than surgery for carriers of BRCA

Howard Smith MD, AM Mar 14, 2024

MR Imaging Saves Breast Cancer Patients: Those with BRCA1 breast cancer enjoy a 3.5-fold lower risk of mortality compared with those not monitored with MR. #breast #cancer #BRCA1 #MR #magneticresonance #imaging #mortality
https://www.instagram.com/p/C4gQ6IVr85r/

Susan Larson ♀️🏳️‍🌈🏳️‍⚧️🌈Oct 17, 2023

I #learned from my own #diagnosis you can still get #BreastCancer with no #familyhistory.

The author thought no family history of breast cancer meant she wasn't at risk for the disease. But then she was diagnosed with stage-one #cancer.

#Women #Transgender #LGBTQ #LGBTQIA #Health #Healthcare #Cancer #BreastCancer #BRCA1 #BRCA2

https://www.insider.com/no-family-history-breast-cancer-diagnosis-2023-10

No family history of breast cancer doesn't mean you can't get disease

The author thought no family history of breast cancer meant she wasn't at risk for the disease. But then she was diagnosed with stage-one cancer.

Insider

The EMBO Journal Jun 22, 2023

A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle

https://www.embopress.org/doi/full/10.15252/embj.2022111951