SciTech Chronicles. . . . . . . . .Mar 8th, 2025
#BRCA1 #BRCA2 #PARPi #cytotoxicity #Basra #Mesopotamia #irrigation #Euphrates #diabetes #gut #beta-cells #C.dubliniensis #ionosphere #thermosphere # Meridian-Project #TIEGCM #kelps #micronutrients #biosorption #phytomining
How to make cancer cells more sensitive to treatment. 💊
Preprint from Hasan Mamar & team shows that the loss of POLE4 - component of POLε - contributes to PARPi sensitivity, regardless of BRCA status.
First preLight from Audrey Noireterre, check it out! 👀
#preLight 👉 https://prelights.biologists.com/highlights/the-loss-of-dna-polymerase-epsilon-accessory-subunits-pole3-pole4-leads-to-brca1-independent-parp-inhibitor-sensitivity-v2/
PARP inhibitors (#PARPi) resistance is ubiquitous in the clinic. A newly discovered pan-PARP inhibitor, thioparib, is highly effective against #olaparib -resistant cancer models, which suggests that therapeutic vulnerabilities still exist in PARPi-resistant tumors.
By JY lang, ZH Miao, A Zhang, JX He & colleagues at Chinese Academy of Sciences, Shanghai, China & University of Chinese Academy of Sciences, Beijing, China
John Vaccaro (johniac)
The EMBO Journal
preLights
EMBO Mol. Medicine