Mastodawn

JAMA Patient Page

📌 Worldwide, ovarian cancer is the eighth most common malignancy and cause of cancer death. In 2022, ovarian cancer was diagnosed in about 325 000 individuals and caused 206 839 deaths.

📌 Risk factors include older age (the most common age at diagnosis is 63 yrs), a family history of breast cancer or ovarian cancer, endometriosis and never having given birth. About 25% are due to inherited genetic variants, primarily in BRCA1 and BRCA2 genes.

3i/Atlas Jun 6

Ovarian cancer wonder drug, and the birth of black holes
https://atlas.whatip.xyz/post.php?slug=ovarian-cancer-wonder-drug-and-the-birth-of-black-holes
Key insight: <p>In this episode
#ovarian #cancer #wonder #black

Ovarian cancer wonder drug, and the birth of black holes

In this episode, we hear about a breakthrough drug called mirvetuximab, which has been dubbed a "biological missile" in the treatment of ovarian cancer. Plus, astronomers suggest some black ...

Scientific Frontline Mar 3

Fecal transplants from older, #estropausal female mice significantly improve #ovarian function, reduce tissue inflammation, and enhance overall fertility in younger female mice.
#Gerontology #ReproductiveBiology #Microbiology #sflorg
https://www.sflorg.com/2026/03/bio03032601.html

Fecal Transplants from Older Mice Significantly Improve Ovarian Function and Fertility in Younger Mice

The surprising findings shed light on the little-known relationship between the microbiome and the reproductive system.

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Wordmark Feb 26

My mother died of #ovarian #cancer, my uncle died of #lungcancer i wonder who is next (both never smoked much)

Scientific Frontline Feb 9

#Ovarian #cancer cells accelerate their spread by recruiting protective #mesothelial cells from the abdominal lining to form hybrid spheres, rather than traveling alone.
#Oncology #CellBiology #Biology #sflorg
https://www.sflorg.com/2026/02/ongy02092601.html

Scientists now know why ovarian cancer spreads so rapidly in the abdomen

Ovarian cancer kills more women than any other gynecological cancer.

Scientific Frontline Jan 5

#Ovarian #cancer often goes undetected for a long time. In seven out of 10 patients, the tumor has already formed secondary #tumors in the #abdominal cavity at the time of diagnosis. These metastases are particularly common in a tissue called the #omentum , also known as the peritoneal apron.
#Oncology #sflorg
https://www.sflorg.com/2026/01/ongy01052601.html

When ovarian cancer alters the abdominal cavity

Ovarian cancer often forms secondary tumors, especially in a certain tissue in the abdominal cavity known as the omentum.

Howard Smith MD, AM Oct 31, 2025

New Weapon Against Breast Cancer. A new, supercharged form of immunotherapy for breast cancer has just been announced by UCLA oncologists. #immunotherapy #CARNKT #cancer #breast #triplenegative #ovarian #pancreatic #lung
https://www.instagram.com/p/DQdod3Mj3HW/

Howard G. Smith MD, AM on Instagram: "#deafness #children #congenital #otoferlin #dboto deafness, children, congenital, otoferlin, dboto ========================== FUTURE MED ========================== New Weapon Against Breast Cancer A new, supercharged form of immunotherapy for breast cancer has just been announced by UCLA oncologists in the Journal of Hematology & Oncology. The new approach involves the production of CAR-NKT cells, standing for chimeric antigen receptor-natural killer T cells, that have the superpower to attack not one but dozens of tumor cell surface antigens simultaneously. The cells target a protein mesothelin, which cancers need to rapidly grow and spread. Many current immunotherapies only target a single receptor. Triple negative breast cancers lack many of these common receptors making them difficult to treat successfully. This CAR-NKT therapy attacks so many receptors it could prove effective for those with these triple negative cancers. Even better, the CAR-NKT cells can be mass-produced from donated stem cells and stored for immediate use on demand. Very promising is the fact that the CAR-NKT cells target, mesothelin, is not only found on breast cancers but also on the surfaces of ovarian, pancreatic, and lung cancer cells. So far, these CAR-NKT cells have only been tested in the laboratory on tissue cultured breast cancer cells harvested from patient swith advanced disease. Clinical trials are in the planning stages, and hopefully, this super-immunotherapy will be available to save patients with a variety of difficult-to-treat cancers…..someday soon. https://www.news-medical.net/news/20251022/New-type-of-immunotherapy-could-change-the-treatment-plan-for-triple-negative-breast-cancer.aspx https://jhoonline.biomedcentral.com/articles/10.1186/s13045-025-01736-9 #immunotherapy #CAR-NKT #cancer #breast #triplenegative #ovarian #pancreatic #lung"

UCLA scientists have made a significant breakthrough in the fight against triple-negative breast cancer with the discovery of a super-immunotherapy. This revolutionary treatment uses CAR-NKT cells to attack multiple tumor cell antigens, offering new hope for patients with this aggressive form of breast cancer. The CAR-NKT cells can be mass-produced from donated stem cells and stored for immediate use, making it a promising treatment option for those with triple-negative breast cancer.

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Howard Smith MD, AM Aug 17, 2025

Wiping Out Ovarian Cancer Protective Cells. Univ. of Chicago oncologist attack ovarian cancer by destroying the cells that protect it from therapy. #ovarian #cancer #immunotherapy #supportcells #nnmt

https://www.instagram.com/p/DNd8M5osKnr/

Howard G. Smith MD, AM on Instagram: "Wiping Out Ovarian Cancer Protective Cells Ovarian cancer cells tend to be resistant to the best cancer therapies including chemo-, radiation-, and immuno. University of Chicago OB-GYN oncologists, collaborating with the National Cancer Institute’s Experimental Therapeutics researchers, now look to a novel approach that seeks to disarm the so-called Cancer Associated Fibroblasts, CAFs, that provide protective cover for the cancer cells themselves. A tumor-induced enzyme NNMT is necessary for normal fibroblasts to convert into the CAFs that shield the ovarian cancer cells by suppressing the body’s immune no reaction to them and permit the cancer to flourish and metastasize to other parts of the body. The UChicago team developed a powerful NNMT inhibitor compound that successfully halts this transformation at least in a preclinical mouse ovarian cancer model. Administering this drug along with immune checkpoint inhibitors effectively halted tumor growth. This approach may finally yield effective therapy for rapidly growing and metastasizing ovarian cancers……someday soon. https://www.mdlinx.com/news/study-shows-targeting-non-cancerous-cells-can-overcome-ovarian-cancer-resistance/53IjD18lCQWOoEEBUYZyh3?show_order=5&utm_campaign=reg_evening-edition_250805_daily-nl-pm-v4_registered-users-a180-all&utm_source=iterable&utm_medium=email https://www.nature.com/articles/s41586-025-09303-5 #ovarian #cancer #immunotherapy #supportcells #nnmt"

Researchers at the University of Chicago and the National Cancer Institute have made a groundbreaking discovery that may provide an effective therapy for ovarian cancer. By targeting Cancer Associated Fibroblasts (CAFs) and the tumor-induced enzyme NNMT, scientists have developed a powerful inhibitor compound that blocks the transformation of normal fibroblasts into CAFs, effectively halting tumor growth. This innovative approach may hold the key to improving survival rates and quality of life for ovarian cancer patients.

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PLOS Biology Jun 26, 2025

Reproductive #aging is associated with declining #fertility and increasing #inflammation. @spangas &co explore a @PLOSBiology study that uses cutting-edge tech to characterize the role of multinucleated giant cells in #ovarian aging. Paper: https://plos.io/3T84WE0 Primer: https://plos.io/3HXKN1b

Howard Smith MD, AM Mar 11, 2025

Improving Ovarian Cancer Immunotherapy: Cancer immunologists at the University of Virginia have now discovered what underlies this failure. #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin
https://www.instagram.com/reel/DHDygk-shuL/

Howard G. Smith MD, AM on Instagram: "Improving Ovarian Cancer Immunotherapy Immunotherapy has been a resounding success for melanoma skin cancer and small cell lung cancer. Not so for ovarian cancer. Cancer immunologists at the University of Virginia have now discovered what underlies this failure. Their research discovered that flagellin protein from gut bacteria blocks the effectiveness of the checkpoint inhibitors that power most current immunotherapy. This bacterial flagellin inhibits immune cell communication helping tumors flourish rather than die. Using a mouse model and blocking flagellin action restored immunotherapeutic effectiveness with 80% of treated animals enjoying long-term tumor control. If this approach is effective for human ovarian cancer patients, coupling flagellin blocking with checkpoint immunotherapy may be a winning therapeutic strategy …..someday soon. https://newsroom.uvahealth.com/2025/02/11/ovarian-cancer-discovery-could-turn-ailed-treatment-into-lifesaver/ https://aacrjournals.org/cancerimmunolres/article-abstract/doi/10.1158/2326-6066.CIR-24-0513/751676/TLR5-signaling-causes-dendritic-cell-dysfunction?redirectedFrom=fulltext #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin"

0 likes, 0 comments - drhowardsmithreports on March 11, 2025: "Improving Ovarian Cancer Immunotherapy Immunotherapy has been a resounding success for melanoma skin cancer and small cell lung cancer. Not so for ovarian cancer. Cancer immunologists at the University of Virginia have now discovered what underlies this failure. Their research discovered that flagellin protein from gut bacteria blocks the effectiveness of the checkpoint inhibitors that power most current immunotherapy. This bacterial flagellin inhibits immune cell communication helping tumors flourish rather than die. Using a mouse model and blocking flagellin action restored immunotherapeutic effectiveness with 80% of treated animals enjoying long-term tumor control. If this approach is effective for human ovarian cancer patients, coupling flagellin blocking with checkpoint immunotherapy may be a winning therapeutic strategy …..someday soon. https://newsroom.uvahealth.com/2025/02/11/ovarian-cancer-discovery-could-turn-ailed-treatment-into-lifesaver/ https://aacrjournals.org/cancerimmunolres/article-abstract/doi/10.1158/2326-6066.CIR-24-0513/751676/TLR5-signaling-causes-dendritic-cell-dysfunction?redirectedFrom=fulltext #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin".

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