katch wreck`Here, we show that decreasing the activity of the #mTOR signaling pathway induces human pluripotent stem cells... & blastoids to enter a dormant state with limited proliferation, developmental progression, & capacity to attach to endometrial cells..similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage & is reversible..The pacing of human #blastocyst development has potential implications for reproductive therapies`
Scientific EuropeanA Mouse can Sense the World Using Regenerated Neurons from Another Species
Interspecies Blastocyst Complementation (IBC) (i.e., complementation by microinjecting stem cells of other species into blastocyst-stage embryos)...........
#Blastocyst #brain #IBC #InterspeciesBlastocystComplementation #Regeneration
SCIEU Team
Steven HiltonThe #Alabama #embyro ruling will be a backdoor to banning #abortion nationwide. If a days-old #blastocyst outside a womb is considered a person, then logically so must a blastocyst inside the womb. This #scotus would like love to make that landmark ruling.
We have to win the white house, win both branches of congress, then immediately expand and pack scotus with judges who can counter the #fascist #christian #theocrats currently dominating the bench.
PLOS Biology#AlternativeSplicing during development. #scRNAseq of mouse #oocyte to #blastocyst reveals large-scale isoform switching & #TransposableElement regulation during the maternal-to-zygotic gene transition #PLOSBiology https://plos.io/4bBFFu1
Single-cell analysis of isoform switching and transposable element expression during preimplantation embryonic development
Alternative splicing is an essential regulatory mechanism for development and pathogenesis. This study uses single cell sequencing of mouse oocyte to plastocyst to reveal large-scale of isoform switching and transposable element regulation during the maternal-to-zygotic gene transition.
CellBioNewsGeneration of #blastocyst-like structures from #spliceosomes represses #mouse #totipotent blastomere-like cells
https://phys.org/news/2023-02-generation-blastocyst-like-spliceosomes-represses-mouse.html
preLightsA new livestock 🐄 embryo model from a self-renewing source.
📄 https://prelights.biologists.com/highlights/bovine-blastoids/
Check out this #preLight from Carly Guiltinan #ucdavis. She covers a #preprint led by Carlos A. Pinzón-Arteaga that reports an efficient method to generate bovine blastocyst-like structures (termed blastoids).
Biology OpenIn this article, Sophie Kraunsoe et al. explore the role of STAT3 and TFCP2L1 in #epiblast renewal, and find that requirements for stem cell #renewal in the dish are different to those in the #embryo:
Check out this interview with Sophie to find out more about the story behind the paper:
https://journals.biologists.com/bio/article/12/1/bio059812/286607/First-person-Sophie-Kraunsoe
#Pluripotency #Diapause #Blastocyst #StemCells #Science #BiologyOpen #Biology #Development #DevBio
Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro
Summary: Inducing diapause in mouse embryos demonstrates that STAT3 and TFCP2L1 are essential for self-renewal of the epiblast, but only TFCP2L1 is also required for derivation of embryonic stem cells.