In this Review, Janet Stott and Catarina Vicente (University of Oxford) propose an in-depth framework for science public engagement projects that can potentially bring together academics from diverse disciplines.

https://journals.biologists.com/bio/article/13/3/bio060108/345670/Interdisciplinary-public-engagement-untapped

“Any good quality two-way public engagement should benefit both researchers and the public.”

#scienceoutreach #publicengagement #community #OpenAccess #BiologyOpen

Interdisciplinary public engagement: untapped potential?

Summary: We propose that interdisciplinary public engagement (public engagement projects that bring together academics from several academic disciplines) is a novel and potentially mutually beneficial approach to engage the public.

The Company of Biologists

This Meeting Review by Matheus Sanita Lima et al (Western University, Canada) provides a comprehensive summary of the 53rd Ontario Ecology, Ethology, and Evolution Colloquium that took place at Western University on 25-27 May 2023.

https://journals.biologists.com/bio/article/13/3/bio060175/344058/Ecology-ethology-and-evolution-in-the-Anthropocene

“We believe biologists, regardless of their chosen subfield of study, are strategically positioned to assess, predict, and mitigate what lies ahead of life on Earth.”

#Anthropogenic #climatechange #biodiversity #OpenAccess #BiologyOpen

Ecology, ethology, and evolution in the Anthropocene

Summary: This Meeting Review summarizes the panel discussions during the 53rd Ontario Ecology, Ethology, and Evolution Colloquium (OE3C 2023), which centred on surviving the Anthropocene under pressing planetary issues.

The Company of Biologists

This work by Laura A. Sherer et al (University of Minnesota) describes two MATLAB programming languages to accurately analyse bundling of actin filaments obtained in fluorescence micrographs.

https://journals.biologists.com/bio/article/13/3/bio060267/344042/Computational-tools-for-quantifying-actin-filament

“With minor modifications, we anticipate that these programs can be made applicable to the analysis of a broad range of polymer-based assays.”

#methodsandtechniques #MATLAB #fluorescence #microscopy #analysis #OpenAccess #BiologyOpen

Computational tools for quantifying actin filament numbers, lengths, and bundling

Summary: We describe two programs written in the MATLAB programming language that facilitate counting, length measurements, and quantification of bundling of actin filaments visualized in fluorescence micrographs.

The Company of Biologists

Here, Ming-Hsuan Wen et al (University of Cambridge) show that nuclear reprogramming is present in meiotic oocytes and does not require cell division.

https://journals.biologists.com/bio/article/13/3/bio060011/344057/Deterministic-nuclear-reprogramming-of-mammalian

“A major difference between oocyte nuclear transfers and iPSC approach concerns the timing of the changes induced.”

#meiosis #nuclearreprogramming #stemcells #therapy #OpenAccess #BiologyOpen

Deterministic nuclear reprogramming of mammalian nuclei to a totipotency-like state by Amphibian meiotic oocytes for stem cell therapy in humans

Summary: Stem cell therapy has shed light on incurable diseases. We describe a novel method for cell reprogramming and provide personalized stem cell sources for stem cell therapies.

The Company of Biologists

This study by Abigail Ama Koomson et al (New York University Abu Dhabi) shows that exposure to high levels of inorganic arsenics during development of zebrafish embryos can significantly affect survival and reproductive health.

https://journals.biologists.com/bio/article/13/3/bio060094/344101/Sustained-effects-of-developmental-exposure-to

“No studies to date have investigated the persistent effects of iAs on the liver in zebrafish”

#zebrafish #inorganic #arsenics #OpenAccess #BiologyOpen #reproduction #survival #geneexpression

Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish

Summary: This work investigates the long-term effects of developmental exposure to inorganic arsenic (iAs) in zebrafish. Fish that were exposed to iAs during development had increased mortality as adults, sustained changes to gsto2 expression in female livers and decreased mating success.

The Company of Biologists

Ivan Mestres et al (Technische Universität Dresden) show that the previously uncharacterised Soluble-Lamin Associated Protein (SLAP) directly influences brain development in mammals.

https://journals.biologists.com/bio/article/13/3/bio060359/344125/Manipulation-of-the-nuclear-envelope-associated

“Here we show that SLAP is critical to maintain nuclear integrity and that alterations in its expression influence neural stem cell fate as well as migration and molecular identity of newborn neurons.”

#nuclearenvelope #mammals #brain #OpenAccess #BiologyOpen

Manipulation of the nuclear envelope-associated protein SLAP during mammalian brain development affects cortical lamination and exploratory behavior

Summary: Far from solely providing a physical barrier separating the genome from the cytoplasm, the nuclear envelope is also instrumental in tuning the fate of neural stem cells influencing cortical lamination and neurodevelopmental disorders.

The Company of Biologists

Elisa Thoral et al (Lund University, Lund, Sweden) show that in wild great tits, unlike in mammals, there is no correlation between resting metabolic rate and mitochondrial respiration.

https://journals.biologists.com/bio/article/13/3/bio060302/344150/The-relationship-between-mitochondrial-respiration

“An ancillary goal was also to investigate the relationship between blood mitochondrial respiration and blood cell count.”

#Mitochondria #Science #BiologyOpen #OpenAccess

The relationship between mitochondrial respiration, resting metabolic rate and blood cell count in great tits

Summary: Our results show that the relationship between resting metabolic rate and blood mitochondrial metabolism depends on the level of cellular permeabilization as well as the level of activation of the electron transport chain. No relationship was detected between blood mitochondrial respiration and blood cell count in our conditions.

The Company of Biologists

This study by Victor Gonzalez et al shows that bees express weak plasticity/low capacity to enhance heat tolerance through acclimation in response to critical thermal maximum.

https://journals.biologists.com/bio/article/13/3/bio060179/344191/Bees-display-limited-acclimation-capacity-for-heat

“Therefore, we hypothesized that larger bees would display greater plasticity in CTMax when compared with small bees, an expectation consistent with the climatic variability hypothesis.”

#climatechange #Science #BiologyOpen #OpenAccess

Bees display limited acclimation capacity for heat tolerance

Summary: Bees display limited capacity to increase their heat tolerance following short-term acclimation and acute heat exposure.

The Company of Biologists

Emily Bulger, Todd McDevitt and Benoit Bruneau show how CDX2 dose-dependently regulates #gene expression in the extraembryonic mesoderm in a #2D gastruloid model.

https://journals.biologists.com/bio/article/13/3/bio060323/345077/CDX2-dose-dependently-influences-the-gene

“This model allows us to investigate how specific genes active during early gastrulation augment cell identity and how changes in adjacent tissues influence cell-cell communication and the gene regulatory networks underlying lineage emergence.”

#Gastrulation #Science #BiologyOpen #OpenAccess

CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development

Summary: Using 2D human gastruloids, CDX2 is shown to dose-dependently influence genes related to tissue permeability, cell-cell adhesions, and cytoskeletal architecture during extraembryonic mesoderm development.

The Company of Biologists

Gary C. Packard shows that #ontogenetic changes in the morphology of eels, lobsters and other aquatic animals are not necessarily accompanied by changes in the pattern of metabolic allometry.

https://journals.biologists.com/bio/article/13/3/bio060317/345084/Discontinuous-biphasic-ontogenetic-shifts-in-the

“While growth by both eels and lobsters doubtless elicits changes in surface area and sites for gas exchange, these changes have no discernable effect on patterns of metabolic allometry."

#Americaneel #Spinylobster #Science #BiologyOpen #Biology

Discontinuous, biphasic, ontogenetic shifts in the metabolic allometry of aquatic animals?

Summary: Allometric variation in metabolic rate is described by a straight line in a bivariate plot of logarithmic transformations of data for both American eels and spiny lobsters.

The Company of Biologists