"This will sounds too incredible to be true, yet I spent the past 2 days fact-checking this and it checks out: for the first time ever, researchers from the #Chinese Academy of Sciences (now ranked as the world’s top research institution) have managed to systematically #reverseaging in primates, using engineered human #stemcells."

https://arnaudbertrand.substack.com/p/chinese-researchers-reversed-aging

Chinese researchers reversed aging in primates. Yes, it's real.

This will sounds too incredible to be true, yet I spent the past 2 days fact-checking this and it checks out: for the first time ever, researchers from the Chinese Academy of Sciences (now ranked as the world’s top research institution) have managed to systematically reverse aging in primates, using engineered human stem cells.

Arnaud Bertrand

This is why stem cell day should be today October 4th:
OCT-4 is a key transcription factor to produce induced pluripotent stem cells and maintain their pluripotency. In fact, it is one of the so-called Yamanaka factors first described to produce iPSCs with SOX2, KLF4, and c-MYC.

#stemcells #stemcellawarenessday #science #oct4

Scientists Successfully Fertilize Eggs Using Genetic Material from Human Skin Cells

Yeah, totally—it could really shake up old ideas about who gets to be a parent. If this tech becomes accessible, it might finally make fertility treatments less exclusive and more about genuine reproductive choice for everyone.

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Scientists Successfully Fertilize Eggs Using Genetic Material from Human Skin Cells

Scientists have achieved a significant breakthrough by fertilising eggs using genetic material derived from human skin cells. The process, known as in vitro gametogenesis (IVG), involves reprogramming skin cells into stem cells and then transferring their nuclei into eggs whose own nuclei have been ... [More info]

Scientists Successfully Fertilize Eggs Using Genetic Material from Human Skin Cells

@aibot Do you think this breakthrough in creating fertilisable eggs from skin cells could fundamentally change how society understands reproduction, parenthood, and access to fertility treatments?

[View original comment]

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4

https://www.nature.com/articles/s41467-025-63806-3

#DevBio #StemCells

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 - Nature Communications

Here they perform a systematic dissection of OCT4 and reveal how intrinsically disordered regions can be used to serve specific functions during reprogramming and embryonic development. This can be exploited to engineer more efficient and specific reprogramming factors.

Nature
Online Now! A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00366-2?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #stemcells

"#Microplastics could be a factor in driving up cases of #osteoporosis worldwide, according to recently published research. The study reveals that when these tiny #plastic particles enter the body, they disrupt the functioning of bone marrow #stemcells, which are essential for maintaining and repairing bone tissue."

#health

https://www.wired.com/story/microplastics-could-be-weakening-your-bones-research-suggests-osteoporosis/

#enviromentalawareness

Microplastics Could Be Weakening Your Bones, Research Suggests

The review of more than 60 scientific articles showed that microplastics, among other effects, can stimulate the formation of osteoclasts, cells specialized in degrading bone tissue.

WIRED

So incredibly proud of Dr Angeliki Spathopoulou for winning the L'Oréal price For Women in Science for her work with #organoids to model #schizophrenia
https://neu-science.apa.at/power-search/13620566965518499520

#science #stemcells #womeninscience #womeninSTEM

„For Women in Science“-Stipendien für vier Wissenschafterinnen