Biology OpenIn this article, Sophie Kraunsoe et al. explore the role of STAT3 and TFCP2L1 in #epiblast renewal, and find that requirements for stem cell #renewal in the dish are different to those in the #embryo:
Check out this interview with Sophie to find out more about the story behind the paper:
https://journals.biologists.com/bio/article/12/1/bio059812/286607/First-person-Sophie-Kraunsoe
#Pluripotency #Diapause #Blastocyst #StemCells #Science #BiologyOpen #Biology #Development #DevBio
Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro
Summary: Inducing diapause in mouse embryos demonstrates that STAT3 and TFCP2L1 are essential for self-renewal of the epiblast, but only TFCP2L1 is also required for derivation of embryonic stem cells.