Scientists share #single_cell #atlas for the highly regenerative #worm, #Pristina leidyi.

#annelids #pluripotency

https://phys.org/news/2024-04-scientists-cell-atlas-highly-regenerative.html

Aurora B actively drives abscission in pluripotent mouse Embryonic Stem Cells via the stabilisation of microtubule bridges.

Ines Jmel-Boyer covers a recent preprint from the Chaigne Lab on #preLights! 👀 ⬇️

#preLight 👉 https://prelights.biologists.com/highlights/aurora-b-controls-microtubule-stability-to-regulate-abscission-dynamics-in-stem-cells-2/

#preprint #biology #StemCells #pluripotency #microtubules

"While endogenous #retroviruses (ERVs) are essential for early development..precise role..remains mysterious. Using cutting-edge #genetic & biochemical techniques in mice, we identify MERVL-gag, a retroviral protein, as a crucial modulator of pluripotent factors OCT4 & SOX2 during lineage specification. MERVL-gag tightly operates with URI, a prefoldin #protein that concurs with #pluripotency bias in mouse #blastomeres..required for totipotency-to-pluripotency transition"

https://www.science.org/doi/10.1126/sciadv.adk9394

"Here, we demonstrate that the #midbody (MB) matrix is the site of ribonucleoprotein assembly and is enriched in mRNAs that encode proteins involved in cell fate, #oncogenesis, and #pluripotency, which we are calling the MB granule. Both MBs and post-abscission MBRs are sites of spatiotemporally regulated translation, which is initiated when nascent daughter cells re-enter G1 and continues after #extracellular release"

https://www.sciencedirect.com/science/article/pii/S153458072300357X?via%3Dihub

When does the embryo finally lose #pluripotency?

Ceren Pajanoja and team at the #KerosuoLab identify a transcriptional signature of pluripotency that is maintained throughout #neurulation in the #ectoderm.

New #preLight written by Andrew Montequin.

👉 https://prelights.biologists.com/highlights/maintenance-of-pluripotency-in-the-entire-ectoderm-enables-neural-crest-formation/

And we also welcome Austin Smith @AustinS10301165 - our @LSI_Exeter institute Director to twitter! (who has a great postdoc position open right now) #bioinformatics #stemcells
#pluripotency @jobRxiv

Apply here
https://tinyurl.com/5n7446ns

In this article, Sophie Kraunsoe et al. explore the role of STAT3 and TFCP2L1 in #epiblast renewal, and find that requirements for stem cell #renewal in the dish are different to those in the #embryo:

https://journals.biologists.com/bio/article/12/1/bio059650/286608/Requirement-for-STAT3-and-its-target-TFCP2L1-in

Check out this interview with Sophie to find out more about the story behind the paper:
https://journals.biologists.com/bio/article/12/1/bio059812/286607/First-person-Sophie-Kraunsoe

#Pluripotency #Diapause #Blastocyst #StemCells #Science #BiologyOpen #Biology #Development #DevBio

Martha Montané-Romero et al. explore novel roles for #PLPP3 in #pluripotency exit and endodermal #differentiation in mouse embryonic stem cells:

https://journals.biologists.com/bio/article/12/1/bio059665/286423/Plpp3-a-novel-regulator-of-pluripotency-exit-and

#Lipids #StemCells #YAP1 #HIPPO #DevBio #Development #Science #BiologyOpen #Biology #AcademicMastodon

I'm really excited to share our #preprint containing a big chunk of my #postdoc work in the Reik Lab at the Babraham Institute.

We wanted to understand how #DNAMethylation and oxidation affect the #enhancer landscape and #GeneExpression as #ESCs exit #pluripotency.

https://biorxiv.org/content/10.1101/2023.01.11.523441v1

#Genomics #PhD #AcademicMastodon #Paper #DevBio