New study unveils unique roles of yeast protein complexes in cellular lifespan
Assistant Professor Takahiro Kosugi from the Institute for Molecular Science, assistant Professor Yoshiaki Kamada at the National Institute for Basic Biology, and colleagues have developed an advanced molecular cell biology approach by integrating computational redesigning of protein complexes based on the predicted three-dimensional structure in yeast genetics.
Researchers discover how cysteine activates a key regulator of cell growth in yeast
Amino acids are the building blocks of life. We obtain them from the food we eat, and the body uses them to make proteins, which in turn are used for growth, development, and a multitude of other functions. However, before the body can build with these blocks, it must first be able to sense their presence.
The#ribosome-associated
#chaperone #Zuo1 controls translation upon
#TORC1 inhibition
Adrien Rousseau and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2022113240Incredibly happy our work on regulation of TOROID (dis)assembly by EGOC is finally published in @NatureSMB! Fantastic collaboration between @LoewithLab, Gutsche and Savvides labs. Many congrats to co-authors Manoël, Clélia, Lenny and @a_desfosses.
https://www.nature.com/articles/s41594-022-00912-6#structuralbiology #cryoEM #cellbiology #TOROID #TORC1
EGOC inhibits TOROID polymerization by structurally activating TORC1 - Nature Structural & Molecular Biology
Determination of the high-resolution structure of yeast TORC1 allows characterization of the precise interfaces of interaction between inactive TORC1 and TORC1′ polymers and identification of the mode of binding of active EGOC on TORC1.
How do
#nutrient-starved cells preserve a basal supply of dormant
#ribosomes?
Michael Hall and colleagues (Biozentrum Basel) identify conserved
#TORC1 #phosphorylation and inhibition of ribosome-binding factor
#Stm1/#SERBP1 in
#yeast and human cells
https://www.embopress.org/doi/10.15252/embj.2022112344
CellBioNews
The EMBO Journal
Jan Felix