Researchers discover how #cysteine activates a key #regulator of #cell #growth in #yeast.
https://phys.org/news/2023-12-cysteine-key-cell-growth-yeast.html
Amino acids are the building blocks of life. We obtain them from the food we eat, and the body uses them to make proteins, which in turn are used for growth, development, and a multitude of other functions. However, before the body can build with these blocks, it must first be able to sense their presence.
Q. Do the #Bacteria involved in meat going off produce Cysteine?
Expanded: Read maybe 6 weeks ago on Mastodon about how hunter gatherers would eat putrifying meat. And I'm wondering if that changed the ratios of proteins that they were eating.
Why might that be of interest?
R.V. Sekhar has had 2 articles published about increasing #Cysteine to boost #Glutathione levels.
http://doi.org/10.3390/nu14051114 2022
https://doi.org/10.1093/gerona/glac135 2023
#RVSekhar
#Brain #Biology
Determinants of length of life are not well understood, and therefore increasing lifespan is a challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial dysfunction contribute to the aging process, but it is unclear if they could also impact lifespan. Glutathione (GSH), the most abundant intracellular antioxidant, protects cells from OxS and is necessary for maintaining mitochondrial health, but GSH levels decline with aging. Based on published human studies where we found that supplementing glycine and N-acetylcysteine (GlyNAC) improved/corrected GSH deficiency, OxS and mitochondrial dysfunction, we hypothesized that GlyNAC supplementation could increase longevity. We tested our hypothesis by evaluating the effect of supplementing GlyNAC vs. placebo in C57BL/6J mice on (a) length of life; and (b) age-associated GSH deficiency, OxS, mitochondrial dysfunction, abnormal mitophagy and nutrient-sensing, and genomic-damage in the heart, liver and kidneys. Results showed that mice receiving GlyNAC supplementation (1) lived 24% longer than control mice; (2) improved/corrected impaired GSH synthesis, GSH deficiency, OxS, mitochondrial dysfunction, abnormal mitophagy and nutrient-sensing, and genomic-damage. These studies provide proof-of-concept that GlyNAC supplementation can increase lifespan and improve multiple age-associated defects. GlyNAC could be a novel and simple nutritional supplement to improve lifespan and healthspan, and warrants additional investigation.
#Redox-sensitive #oligomerization of specific #cysteine residues makes #autophagy receptor #NDP52 a sensor of ROS from damaged #mitochondria, which initiates #PINK1/#Parkin-mediated #mitophagy
Victor Korolchuk and collaborators, University of Newcastle
Referenced link: https://phys.org/news/2022-09-coral-genome-reveals-cysteine.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-09-coral-genome-reveals-cysteine.html
Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1573371643417829377#m
Coral #genome reveals #cysteine surprise @kaust_news @ScienceAdvances https://phys.org/news/2022-09-coral-genome-reveals-cysteine.html
Model animals, such as mice and fruit flies, have provided scientists with powerful insights into how cellular biology works. However, model animals are really just a guide, and it can be risky to generalize findings across animals from studying a selection of model organisms.
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