Mastodawn

Not for nothing, but after 30 years of trying to treat my treatment resistant depression, I'm a little over a month into Spravato (esketamine) treatment and it seems to be the only thing that's made a difference without intolerable side effects. In fact, I don't remember a time in my life ever when I've felt this way. The heaviness has lifted, not to be replaced by temporary mania or numbness, but a sort of objective clearness. I still have meltdowns and lapses, but they are growing fewer and I can better see them coming. I no longer feel trapped by them or inside of them. I feel more like I walk beside them. I hold their hand and try to navigate the world together. When I can. When I can. Sometimes they rush ahead. But my relationship with my depression is changing. We are equals now. I am learning to converse with it instead of letting it dictate the terms.

@PsychedelicInstitute https://mastodon.social/@PsychedelicInstitute/116216070749936835

#MentalHealth #TreatmentResistentDepression #TRD #Spravato #Esketamine

Psychedelic Institute Feb 28

https://link.springer.com/article/10.1007/s12671-023-02206-4 Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies (2023) - clear role in supporting psychedelic process, particularly in psychedelic-assisted psychotherapy, likely to prove extremely useful in the preparation, dosing and integration phases. #ketamineassistedpsychotherapy #ketamine #psychedelics #psychedelictherapy #psychedelicassistedpsychotherapy #spravato

Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies - Mindfulness

Objectives The mindfulness-informed intervention that has so far received the most attention as an adjunct to psychedelic-assisted psychotherapy is Acceptance and Commitment Therapy (ACT), but little remains known about potential synergies between psychedelic-assisted psychotherapy and mindfulness-based interventions such as Mindfulness-Based Cognitive Therapy (MBCT). This paper examines and evaluates the therapeutic compatibility of MBCT with psychedelic-assisted psychotherapy, and their potential synergies. Methods This study represents a narrative review of the current literature on psychedelic-assisted psychotherapy and MBCT. Results We demonstrate how MBCT targets core processes including acceptance, being present, concentration, decentering and embracing difficulties — and outline why strengthening these capacities with systematic meditation training may prove invaluable during the preparation, dosing and integration phases of psychedelic-assisted psychotherapy. Conclusions MBCT’s emphasis on systematic training in mindfulness meditation and fostering nonjudgmental presence aligns well with the states of consciousness induced by psychedelics, highlighting its potential to enhance various stages of both the psychedelic experience and subsequent integration. By equipping individuals with effective mindfulness and cognitive restructuring techniques, MBCT may offer advantages beyond those provided by ACT, such as the ability to skillfully navigate and manage challenging experiences that can emerge during different phases of the psychedelic experience and integration. This suggests that MBCT’s unique approach may complement psychedelic-assisted psychotherapy in ways that ACT may not fully address, particularly in the context of handling challenging experiences.

SpringerLink

Psychedelic Institute Feb 28

Industry sponsorship and research outcome (2017) Sponsorship of drug and device studies by the manufacturing company leads to more favorable efficacy results and conclusions than sponsorship by other sources. Our analyses suggest the existence of an industry bias that cannot be explained by standard 'Risk of bias' assessments. #ketamine #esketamine #spravato #psychedelics #psychiatry #nobillionaires https://pubmed.ncbi.nlm.nih.gov/28207928/

Industry sponsorship and research outcome - PubMed

Sponsorship of drug and device studies by the manufacturing company leads to more favorable efficacy results and conclusions than sponsorship by other sources. Our analyses suggest the existence of an industry bias that cannot be explained by standard 'Risk of bias' assessments.

PubMed

Psychedelic Institute Feb 28

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0040286 Ghost Management: How Much of the Medical Literature Is Shaped Behind the Scenes by the Pharmaceutical Industry? (Sismondo, 2007) #esketamine #ketamine #spravato #psychedelics #psychiatry drug companies pay for trials by contract research organizations (CROs), analyze the data in-house, have professionals write manuscripts, ask academics to serve as authors of those manuscripts, and pay communication companies to shepherd them through publication in the best journals.

Ghost Management: How Much of the Medical Literature Is Shaped Behind the Scenes by the Pharmaceutical Industry?

Sismondo discusses how pharmaceutical companies and their agents shape multiple steps in the research, analysis, writing, and publication of articles.

Jürgen 🌗🪐🌌 🇦🇹Feb 27

So, auf geht's zur letzten Ketamin-Erhaltungsinfusion.
22 Infusionen, wöchentlich mit gelegentlichen Pausen (meinerseits bedingt).
Ab März damit einen Fixtermin weniger. 😮‍💨

Gesamte Fahrzeit Klinik H+R über 2 h, Infusion (Esketamin / Ketanest-S) selbst läuft 40 min, mit Vorbereitungszeit, kurzes Gespräch mit dem Doc und bis ich wieder "entlassungsfähig klar im Kopf" bin, nochmal an die 2h.
Und dann komme ich ziemlich hungrig heim (weil nüchtern für die Infusion), eine Wohltat wenn ich dann endlich auf die Couch komme. 😌 Und dort darf sich dann die infusionsbedingte "Restmüdigkeit" abbauen.

Warum eine Infusion und nicht den Nasenspray (Spravato)? Wegen der Krankenkasse. 🤬

#Ketamin #Ketamintherapie #Ketamininfusion #Esketamin #Ketanest #Spravato #ÖGK #OeGK #Krankenkasse #hirnorganischeDepression #Depression

Psychiatric Wellness Oct 13

At Psychiatric Wellness, our compassionate team provides guided Spravato treatment in a calm, supportive environment designed for your comfort and care.

📞 Call (405) 437-0205 or visit https://zurl.co/EVvgB to see if Spravato is right for you.
You don’t have to face depression alone. 💙

#Spravato #TreatmentResistantDepression #MentalWellness #PsychiatricWellness #YouAreNotAlone

Psychedelic Institute Sep 26

Spotlight: First study to compare two ketamine therapies for patients with severe depression
IV ketamine found to offer faster response with greater improvements than FDA-approved intranasal esketamine (Spravato) https://psychedelicmentalhealth.net/iv-ketamine-therapy-more-effective-than-spravato-esketamine-severe-depression/ #ketamine #ketaminetherapy #psychedelicresearch #mentalhealth #depression #psychedelics #neuroscience #esketamine #spravato

Spotlight: First study to compare two ketamine therapies for patients with severe depression

IV ketamine found to offer faster response with greater improvements than FDA-approved intranasal esketamine (Spravato)

Psychedelic Institute of Mental Health & Family Therapy

Jürgen 🌗🪐🌌 🇦🇹Aug 21, 2025

"Illegaler Konsum von #Ketamin nimmt zu"

Hierzu kann ich zwar nichts sagen, kenne die dabei auftretende Wirkung auch nicht.

Was ich aber sagen kann: bei der bei einer #Ketamintherapie (#TherapieresistenteDepression) verwendeten Dosis (0,5 mg pro kg KG) ist nix mehr mit "Party". Da liege ich im Krankenhausbett und bin fast nicht in der Lage den Alarmknopf/Rufknopf zu drücken wenn der Finger schon (wie vorbereitet) auf der Taste der Fernbedienung draufliegt. 🤷

https://science.orf.at/stories/3231677/

#Depression #Therapierefraktär #Ketamininfusion #Spravato

Drogen: Illegaler Konsum von Ketamin nimmt zu

Das Narkosemittel Ketamin kommt wegen seiner psychoaktiven Wirkung seit einigen Jahren auch in der Therapie schwerer Depressionen zum Einsatz – doch nur in Ausnahmefällen und unter ärztlicher Aufsicht. Fehlinformationen zur therapeutischen Wirkung von Ketamin dürften nun dazu beitragen, dass der illegale Konsum als Rauschdroge zunimmt.

ORF.at

Jürgen 🌗🪐🌌 🇦🇹Aug 6, 2025

Gibt es hier jemanden die/der schon mal eine #Ketamintherapie hatte?
#Ketamin als Infusion oder Nasenspray (#Spravato)?

#Depression #Esketamin #Depressionen #Antidepressiva #Therapieresistenz #TherapieresistenteDepression

Psychiatric Wellness Jul 28, 2025

💙 Struggling with depression that won’t lift? There’s hope. Spravato (esketamine) is a breakthrough treatment for treatment-resistant depression, offering new possibilities when other options haven’t worked. 🌿✨ Administered in a safe, controlled setting, Spravato can help restore balance and bring relief.

Contact Psychiatric Wellness (405)437-0205 or visit our website https://zurl.co/gEXlU.

We’re here to help. 💙

#Spravato #BreakthroughHealing #YourJourneyOurFocus