Psychedelic-assisted pharmacotherapy: clinical applications and regulatory considerations - PubMed

Psychedelic-assisted therapies are unlikely to follow a conventional prescription model and instead require specialist-delivered, psychotherapy-integrated care under appropriate regulatory and ethical safeguards. While late-stage trials support their potential in high-need populations, unresolved ch …

PubMed
https://link.springer.com/article/10.1007/s12671-023-02206-4 Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies (2023) - clear role in supporting psychedelic process, particularly in psychedelic-assisted psychotherapy, likely to prove extremely useful in the preparation, dosing and integration phases. #ketamineassistedpsychotherapy #ketamine #psychedelics #psychedelictherapy #psychedelicassistedpsychotherapy #spravato
Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies - Mindfulness

Objectives The mindfulness-informed intervention that has so far received the most attention as an adjunct to psychedelic-assisted psychotherapy is Acceptance and Commitment Therapy (ACT), but little remains known about potential synergies between psychedelic-assisted psychotherapy and mindfulness-based interventions such as Mindfulness-Based Cognitive Therapy (MBCT). This paper examines and evaluates the therapeutic compatibility of MBCT with psychedelic-assisted psychotherapy, and their potential synergies. Methods This study represents a narrative review of the current literature on psychedelic-assisted psychotherapy and MBCT. Results We demonstrate how MBCT targets core processes including acceptance, being present, concentration, decentering and embracing difficulties — and outline why strengthening these capacities with systematic meditation training may prove invaluable during the preparation, dosing and integration phases of psychedelic-assisted psychotherapy. Conclusions MBCT’s emphasis on systematic training in mindfulness meditation and fostering nonjudgmental presence aligns well with the states of consciousness induced by psychedelics, highlighting its potential to enhance various stages of both the psychedelic experience and subsequent integration. By equipping individuals with effective mindfulness and cognitive restructuring techniques, MBCT may offer advantages beyond those provided by ACT, such as the ability to skillfully navigate and manage challenging experiences that can emerge during different phases of the psychedelic experience and integration. This suggests that MBCT’s unique approach may complement psychedelic-assisted psychotherapy in ways that ACT may not fully address, particularly in the context of handling challenging experiences.

SpringerLink
Did you know that ketamine and its psychedelic properties have been studied for mental health, pain management and substance use indications since the 1970’s? Find out more at https://psychedelicmentalhealth.net #ketamine #psychedelics #mentalhealth #depression #painmanagement #palliativecare #ketaminetherapy #substanceabuse #alcoholdisorder #psychedelicassistedpsychotherapy
Psychedelic Mental Health

Psychedelic Professional Development | Ketamine-Assisted Psychotherapy Telehealth | Psychedelic Therapist Supervision | Sex Therapy

Psychedelic Mental Health
Breaking: Australia's Department of
Veterans' Affairs Funds Psychedelic
Assisted Therapy Today, the Australian Government's Department of Veterans' Affairs confirmed that it has approved the funding of MDMA for PTSD and psilocybin for treatment-resistant depression (TRD). Both drugs are to be used in combination with "intensive psychotherapy", the department said in
a statement. https://psychedelicalpha.com/live #psychedelics #psychedelic #psychedelictherapy #psychedelicassistedpsychotherapy
The Psychedelic News Feed - Psychedelic Alpha

Your one-stop source for the latest coverage of psychedelics in the media: from policy and culture through to research and business.

Psychedelic Alpha
https://psychedelicmentalhealth.net/psychedelics-ketamine-mental-health-reimagining-care-through-science-insight-and-compassion-mikellides-et-al-2025/ Psychedelics and mental health: reimagining care through science, insight, and compassion (Mikellides, et al, 2025) "These substances are not stand-alone medications; rather, they function as adjuncts to intensive psychotherapeutic processes. Training therapists and establishing ethical, evidence-based protocols is essential." #ketamine #psychedelics #psychedelicassistedpsychotherapy #ketamineassistedpsychotherapy #ketaminetherapy #psychedelictherapy #ketaminetherapy
Psychedelics and mental health: reimagining care through science, insight, and compassion (Mikellides, et al, 2025)

"These substances are not stand-alone medications; rather, they function as adjuncts to intensive psychotherapeutic processes. Training therapists and establishing ethical, evidence-based protocols is essential."

Psychedelic Institute of Mental Health & Family Therapy
https://psychedelicmentalhealth.net/depression-remission-endures-5-years-after-psilocybin-with-psychotherapy/ Spotlight: Psilocybin with psychotherapy trial shows participants in remission for depression 5 years later. "when it comes to reducing depression with psychedelic-assisted therapy, what matters even more than the drug is a strong relationship between the therapist and study participant." #psychotherapy #Psychedelicresearch #psychedelictherapist "#mentalhealth #psilocybin #psychedelics #psychedelictherapy #psychedelicassistedtherapy #psychedelicassistedpsychotherapy
Spotlight: Depression remission endures 5 years after psilocybin trial consisting of psilocybin with psychotherapy (2025)

"when it comes to reducing depression with psychedelic-assisted therapy, what matters even more than the drug is a strong relationship between the therapist and study participant."

Psychedelic Institute of Mental Health & Family Therapy
https://psychedelicalpha.com/news/breaking-fda-publishes-lykos-therapeutics-mdma-complete-response-letter-crl #FDA response letter regarding the rejection of #mdma #psychedelicassistedpsychotherapy includes "The MAPS-based regimen may not be generalizable to all types of psychotherapy practices. We recommend using an evidence-based standard of care psychotherapy in lieu of the MAPS-developed psychotherapy in any future studies." ie -- cognitive behavioral therapy, which the FDA outlines as the standard of #ptsd treatment #mentalhealth #cbt #psychedelics

Is #ketamine a #psychedelic ? https://psychedelicmentalhealth.net/is-ketamine-a-psychedelic/ #psychedelics #ketaminetherapy #psychedelicassistedpsychotherapy #ketamineassistedpsychotherapy

Did you know ketamine was coined a "dissociative anesthetic" by the wife of the chemist who first synthesized it lest its potential use in medicine be ruined due to its association with "classical psychedelics"?

Is ketamine a "psychedelic"?

Yes.

Psychedelic Institute of Mental Health & Family Therapy
Spotlight: Positive Phase 2 Results: Psilocybin-Assisted Psychotherapy Treatment, PSX-001, for Generalized Anxiety Disorder (2025) All participants received equal hours of psychological support and preparation, ensuring that any treatment effect could be attributed to psilocybin itself and not therapeutic bias. #psychedelictherapy #psychedelicassistedpsychotherapy #psilocybin #mushrooms #anxiety #mentalhealth #psychedelicresearch https://psychedelicmentalhealth.net/spotlight-positive-phase-2-results-psilocybin-assisted-psychotherapy-treatment-psx-001-for-generalized-anxiety-disorder-2025/
Spotlight: Positive Phase 2 Results: Psilocybin-Assisted Psychotherapy Treatment, PSX-001, for Generalized Anxiety Disorder (2025)

"All participants received equal hours of psychological support and preparation, ensuring that any treatment effect could be attributed to psilocybin itself and not therapeutic bias."

Psychedelic Institute of Mental Health & Family Therapy
Increasing Access to Psychedelic-Assisted Psychotherapy : The "proliferation of ketamine clinics" narrative and cost considerations

Psychedelic and psychiatric medicines have been studied for over 100 years as adjuncts to psychotherapy, with over 60 years of ongoing research on the off-label use of racemic ketamine, a generic medicine in various routes of administration with varying levels of support care

Psychedelic Institute of Mental Health & Family Therapy