Overcoming Antibiotic Resistance to Tetracycline in Staphylococcus aureus by Gold and Silver Nanoparticles - Cytology and Genetics

Abstract The use of tetracyclines in medicine, veterinary medicine, and stock raising has led to the spread of bacterial resistance to tetracycline, particularly among dangerous representatives of Staphylococcus aureus. Therefore, the analysis of resistance to tetracycline and the creation of approaches to overcome it are extremely relevant. Studies of 64 clinical isolates of S. aureus, which were characterized by moderate biofilm formation, showed that 33 of them contained plasmid DNA. A significant spread (in 96% of studied isolates) of the known transmissible tetracycline resistance genes tet(K) and tet(M) was shown in the examined plasmid-containing doxycycline-resistant clinical isolates of S. aureus. Plasmid-containing doxycycline-resistant clinical isolates with tet(K) and tet(M) genes lost resistance to the tetracycline antibiotic doxycycline after treatment of their cells with gold nanoparticles of 30 nm in a concentration of 3.2–9.6 μg/mL or medium-sized silver of 30 nm in a concentration of 20–40 μg/mL. Elimination of tet genes responsible for acquired resistance was confirmed by PCR.

SpringerLink
Golden eyes see again. A retinal prosthesis with the potential to restore #vision lost or degraded vision due to age-related macular degeneration using gold #nanoparticles, which allows activation of cells in the eye using an infrared laser. Hope it'll work.
Naturally, the visual of it is got me just as interested as the medical implication. Think of the visuals for a Sci-Fi story, ho #writers - the old person with their eye reflecting in gold.
https://pubs.acs.org/doi/10.1021/acsnano.4c14061

🛡️ RNA interference and nanomedicine join forces to fight dangerous fungal infections

https://phys.org/news/2025-03-rna-nanomedicine-dangerous-fungal-infections.html

#healthcare #medicine #biotech #rna #nanoparticles #biology

RNA interference and nanomedicine join forces to fight dangerous fungal infections

Fungal infections are on the rise globally. According to a study by the Manchester Fungal Infection Group, in 2022, approximately 6.5 million people were infected by a pathogenic fungus, and about 3.8 million died as a result—nearly twice as many as in 2012. Even with medications, known as antifungals, the mortality rate for invasive infections caused by the mold Aspergillus fumigatus is as high as 85%. As resistant fungal strains increase, treatment becomes more difficult, and new therapies are urgently needed.

Phys.org

#Nanoparticles! New Drug Delivery Tech Could Change How We Treat Cancer and Alzheimer’s

https://scitechdaily.com/new-drug-delivery-tech-could-change-how-we-treat-cancer-and-alzheimers/

here we go ✊🏼

na recenzi jsem čekala téměř třičtvrtě roku, ale konečně je to venku. a tímto považuji svoji disertaci za vytěženou 🥳

(jako bonus nějaké to “umčo”. objektifikace Ondřeje Lánského in the making)

#nanoparticles #pseudomonas #cannabis

Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS & Atherosclerosis
https://www.science.org/content/article/new-nanoparticle-therapies-target-two-major-killers
https://www.biorxiv.org/content/10.1101/2025.01.09.632179v1
https://news.ycombinator.com/item?id=43535352

Nanoparticle therapies target two major killers
* ARDS: acute respiratory distress syndrome
* atherosclerosis

#nanoparticles #mRNA #ARDS #RespiratoryDistress #VascularDisease #atherosclerosis

26-Mar-2025
Scientists discovered chemical oscillations in #palladium #nanoparticles, paving the way for #recycling precious metal #catalysts

https://www.eurekalert.org/news-releases/1077942 #science #chemistry #sustainability #catalysis

Scientists discovered chemical oscillations in palladium nanoparticles, paving the way for recycling precious metal catalysts

Scientists have for the first time filmed the real-time growth and contraction of Palladium nanoparticles, opening new avenues for utilising and recycling precious metal catalysts.

EurekAlert!
[Biology Open] Comparison of silver and gold nanoparticles green synthesis by Artemisia annua hairy root extracts - #Artemisiaannua #Hairyroots #Silvernanoparticles #Goldnanoparticles #Greensynthesis #nanoparticles #NPs - https://doi.org/10.1242/bio.061739
Not-so-safe! “Flame-free” candles produce millions of nanoparticles per cc of air indoors, pose risk to lungs. https://pubs.acs.org/doi/10.1021/acs.estlett.4c00986 Similar to burning scented candles and using gas stoves indoors, or roadside exposures to diesel and natural-gas combustion engines. See graphical abstract here: https://pubs.acs.org/cms/10.1021/acs.estlett.4c00986/asset/images/medium/ez4c00986_0003.gif
#health #nanoparticles #lungs #pollution