Mastodawn

Overcoming Antibiotic Resistance to Tetracycline in Staphylococcus aureus by Gold and Silver Nanoparticles - #antibioticresistance #Staphylococcusaureus #tetracycline #biofilm #Rplasmids #Staphylococcus #goldnanoparticles #silvernanoparticles #nanoparticles #AuNPs #AgNPs #tetKgene #tetMgene - https://link.springer.com/article/10.3103/S0095452724060021

Overcoming Antibiotic Resistance to Tetracycline in Staphylococcus aureus by Gold and Silver Nanoparticles - Cytology and Genetics

Abstract The use of tetracyclines in medicine, veterinary medicine, and stock raising has led to the spread of bacterial resistance to tetracycline, particularly among dangerous representatives of Staphylococcus aureus. Therefore, the analysis of resistance to tetracycline and the creation of approaches to overcome it are extremely relevant. Studies of 64 clinical isolates of S. aureus, which were characterized by moderate biofilm formation, showed that 33 of them contained plasmid DNA. A significant spread (in 96% of studied isolates) of the known transmissible tetracycline resistance genes tet(K) and tet(M) was shown in the examined plasmid-containing doxycycline-resistant clinical isolates of S. aureus. Plasmid-containing doxycycline-resistant clinical isolates with tet(K) and tet(M) genes lost resistance to the tetracycline antibiotic doxycycline after treatment of their cells with gold nanoparticles of 30 nm in a concentration of 3.2–9.6 μg/mL or medium-sized silver of 30 nm in a concentration of 20–40 μg/mL. Elimination of tet genes responsible for acquired resistance was confirmed by PCR.

SpringerLink

PLOS Biology Apr 22

#Staphylococcus secretes toxins such as PVL to kill immune cells, incl macrophages. This study shows that PVL binds anionic #phospholipids under acidic conditions, targeting lysosomal & mitochondrial #membranes (but not plasma membrane) to promote bacterial escape @PLOSBiology https://plos.io/3RvcArh

Staphylococcal toxin PVL ruptures model membranes under acidic conditions through interactions with cardiolipin and phosphatidic acid

Staphylococcus aureus secretes toxins, such as Panton-Valentine leukocidin (PVL), to kill immune cells, including macrophages. This study shows that PVL binds phosphatidic acid and cardiolipin in acidic conditions, targeting lysosomal and mitochondrial membranes (but not the plasma membrane) to promote bacterial escape.

CellBioNews Feb 19

How #Staphylococcus aureus 'steals' #iron from our #blood during infections.

#kleptophagy #kleptoparasitism #heme

https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html

How Staphylococcus aureus 'steals' iron from our blood during infections

Researchers have revealed how Staphylococcus aureus bacteria extract iron from hemoglobin—a process crucial to their survival during infections. Using a novel time-resolved X-ray solution scattering (TR-XSS) technique, a research team at the ESRF, the European Synchrotron, Grenoble, France, has identified the full sequence of protein–protein interactions during this iron "theft."

Benjamin Carr, Ph.D. 👨🏻‍💻🧬Feb 17

These are the 20 most-studied #bacteria — majority ignored
Model microbes such as Escherichia coli hog scientists’ attention, leaving most known bacteria with few publications devoted to them.
Study of over 43,000 bacterial species found #Ecoli dominates with 21% of all publications, followed by human pathogens like #Staphylococcus aureus. Microbes crucial for human health and Earth's ecosystems remain largely unexplored, Univ of Michigan biologist Paul Jensen reported.
https://www.nature.com/articles/d41586-025-00038-x

These are the 20 most-studied bacteria — the majority have been ignored

Model microbes such as Escherichia coli hog scientists’ attention, leaving most known bacteria with few publications devoted to them.

Angelika Lensen Feb 3

#Gesundheit & Wissenschaft: So schaltet #Staphylococcus aureus das #Immunsystem aus und stört die Wirkung von Impfstoffen https://www.gesundheitundwissenschaft.com/2025/02/so-schaltet-staphylococcus-aureus-das.html #medizin #impfstoff #impfung #bakterien

So schaltet Staphylococcus aureus das Immunsystem aus und stört die Wirkung von Impfstoffen

Aktuelles über Gesundheit, Medizin, Ernährung, Naturheilkunde, Psychologie

Matilda's Lab Dec 20

Here's one for those who hate needles. A common skin bacterium can be used as a means of delivering vaccines by merely rubbing them on the surface of your skin.
https://www.eurekalert.org/news-releases/1067622
#vaccines #sciencenews #staphylococcus

Stanford scientists transform ubiquitous skin bacterium into a topical vaccine

Stanford University scientists’ findings in mice could translate into a radical, needle-free vaccination approach that would also eliminate reactions including fever, swelling and pain.

EurekAlert!

Dr Gaurav Gupta Aug 28, 2024

Osteomyelitis is a bone infection usually caused by bacteria like Staphylococcus aureus. It can also be caused by fungi or tuberculosis bacteria, spreading through blood or tissue.

#Osteomyelitis #BoneInfection #Staphylococcus #InfectionCauses #DrGauravGupta

To know more, watch the video. Here is the link -https://zurl.co/LmzI

- YouTube

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Dr Gaurav Gupta Aug 23, 2024

Bone and joint infections, known as osteomyelitis and septic arthritis, are serious conditions caused by bacteria like Staphylococcus aureus. Swift treatment is crucial.

#BoneInfections #JointInfections #Staphylococcus #Osteomyelitis #SepticArthritis #DrGauravGupta

To know more, watch the video. Here is the link - <https://zurl.co/LmzI>

- YouTube

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Court Cantrell prefers not to Aug 10, 2024

This is your semi-regular reminder to stop what you're doing and sanitize your cell phone, which is a cesspool of germs.

This message is brought to you by #COVID19, #influenza, #staphylococcus, #streptococcus, #EColi, #BacillusCereus, #SAureus, #enterococcus, #MRSA, #rhinovirus, and many more.

Our near-collective habit of taking our phones into the bathroom is a really, really bad idea.

#PSA
#PublicServiceAnnouncement

Laborjournal Aug 3, 2024

Das #Biotech-#Startup HYpharm testet ein #Nasenspray mit Endolysin-Enzymen aus #Phagen, um folgenschwere Besiedelungen der Nasenschleimhaut durch Methicillin-resistente #Staphylococcus-aureus (#MRSA)-#Bakterien zu verhindern. @realtobiasludwig hat die Details für uns: https://www.laborjournal.de/editorials/3057.php

HYpharm entwickelt Phagenenzym-Therapie gegen Bakterien

Das Startup HYpharm aus Bernried entwickelt eine prophylaktische Therapie gegen Staphylococcus aureus und setzt dabei auf Endolysine aus Bakteriophagen

Laborjournal