Long COVID (LC) impacts one in five children after an acute SARS-CoV-2 infection. Typical LC symptoms include fatigue, brain fog, pain, and shortness of breath, which can significantly impact individuals and society. Moreover, LC may impair school performance and have long-term health and develop...
Blood test detecting Long Covid in kids with 94% accuracy microclots
https://www.researchsquare.com/article/rs-7483367/v1
#HackerNews #BloodTest #LongCovid #Kids #Microclots #HealthTech
Long COVID (LC) impacts one in five children after an acute SARS-CoV-2 infection. Typical LC symptoms include fatigue, brain fog, pain, and shortness of breath, which can significantly impact individuals and society. Moreover, LC may impair school performance and have long-term health and develop...
Nailfold Capillaroscopy:
Unveiling Fibrinoid Microclots and Microcirculation Dynamics
https://www.buzzsprout.com/2405788/episodes/17522448
https://helioxpodcast.substack.com/publish/post/168582768
July 21, 2025 • (S5 E3) • 17:20
Heliox: Where Evidence Meets Empathy 🇨🇦
Researchers are now developing smartphone apps that can do preliminary assessments of microcirculation using your phone's camera with a simple lens attachment.
Machine learning systems are already being trained to analyze these images with superhuman accuracy.
Flow Cytometric Detection of Fibrin(ogen) Amyloid Microclots” https://www.buzzsprout.com/2405788/episodes/17447130
On the Utility of Nailfold Capillaroscopy in Detecting the Effects of Fibrinoid Microclots in Diseases Involving Blood Stasis https://www.buzzsprout.com/2405788/episodes/%20https://www.preprints.org/manuscript/202505.2356/v1
#MedicalResearch #ChronicIllness #BloodClots #LongCOVID #HealthScience #Microcirculation #TraditionalMedicine #AI #Diagnostics #Capillaroscopy #microclots #S1 #AmyloidProtein #TissueHypoxia #Covid19 #TeamClots
By @RTHM_Health
"A new study suggests that exercise doesn’t clear microclots in people with Long COVID—it just fragments them into smaller ones. These smaller clots are linked to increased inflammation and impaired oxygen transport, which may help explain post-exertional malaise (PEM) and post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even mild physical or mental effort."
"Researchers observed these microclot and inflammatory changes even after submaximal exertion, highlighting the need for caution when recommending exercise-based therapies."
Want more research breakdowns like this? Sign up for our email list at https://linktr.ee/rthm_health
🔗 DOI: https://doi.org/10.21203/rs.3.rs-6717727/v1
#LongCOVID #ChronicFatigue #pwLC #PostCOVID #rthm_health #LongCOVIDResearch #PESE #PEM #IACC #COVID19 #Microclots @auscovid19
> Although the symptoms of Long COVID are multifarious, we here argue that the ability of these fibrin amyloid microclots (fibrinaloids) to block up capillaries, and thus to limit the passage of red blood cells and hence O2 exchange, can actually underpin the majority of these symptoms. Consistent with this, in a preliminary report, it has been shown that suitable and closely monitored ‘triple’ anticoagulant therapy that leads to the removal of the microclots also removes the other symptoms.
Post-acute sequelae of COVID (PASC), usually referred to as ‘Long COVID’ (a phenotype of COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which symptoms such as breathlessness, fatigue, ‘brain fog’, tissue damage, inflammation, and coagulopathies (dysfunctions of the blood coagulation system) persist long after the initial infection. It bears similarities to other post-viral syndromes, and to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Many regulatory health bodies still do not recognize this syndrome as a separate disease entity, and refer to it under the broad terminology of ‘COVID’, although its demographics are quite different from those of acute COVID-19. A few years ago, we discovered that fibrinogen in blood can clot into an anomalous ‘amyloid’ form of fibrin that (like other β-rich amyloids and prions) is relatively resistant to proteolysis (fibrinolysis). The result, as is strongly manifested in platelet-poor plasma (PPP) of individuals with Long COVID, is extensive fibrin amyloid microclots that can persist, can entrap other proteins, and that may lead to the production of various autoantibodies. These microclots are more-or-less easily measured in PPP with the stain thioflavin T and a simple fluorescence microscope. Although the symptoms of Long COVID are multifarious, we here argue that the ability of these fibrin amyloid microclots (fibrinaloids) to block up capillaries, and thus to limit the passage of red blood cells and hence O2 exchange, can actually underpin the majority of these symptoms. Consistent with this, in a preliminary report, it has been shown that suitable and closely monitored ‘triple’ anticoagulant therapy that leads to the removal of the microclots also removes the other symptoms. Fibrin amyloid microclots represent a novel and potentially important target for both the understanding and treatment of Long COVID and related disorders.
#SARSCoV2 persistence in platelet-producing lung cells:
"Accordingly, in all samples analyzed, circulating MK [megakaryocyte] in Long COVID sheltered both Spike and SARS-CoV-2 ssRNA [single-stranded RNA], but also dsRNA [double-stranded RNA] suggestive of viral replication. [...] Platelets microclots were detected in all tested Long COVID patients."
#covid #covid19 #LongCovid #pandemic #MicroClots #PublicHealth #CovidIsNotOver
Background: We have shown that acute COVID-19 pathophysiology is profoundly altered by infection of lung megakaryocytes (MKs) and platelets by SARS‑CoV‑2 (Zhu et al, 2022). A significant proportion of COVID-19 patients have symptoms persisting for > 3 months after initial infection with SARS-CoV-2, referred to as Long COVID or Post-acute Sequelae of SARS-CoV-2 (PASC) patients.
Long COVID still has no cure — so these patients are turning to research.
With key long COVID trials yet to yield results, people with the condition are trying to change how clinical trials are done.
By Rachel Fairbank
#LongCovid #MicroClots #nattokinase #serrapeptase #lumbrokinase #Putrino
>>We conclude that the presence of fibrinaloid #microclots can indeed significantly account for the symptoms of #POTS associated with #LongCovid (and likely other syndromes), just as they can for other symptoms, post-exertional symptom exacerbation, and the generation of autoantibodies<<
Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890060/
Postural orthostatic tachycardia syndrome (POTS) is a common accompaniment of a variety of chronic, inflammatory diseases, including long COVID, as are small, insoluble, ‘fibrinaloid’ microclots. We here develop the argument, with accompanying ...
New research on severe #microclots and #POTS!
“We here develop the argument, with accompanying evidence, that fibrinaloid microclots, through their ability to block the flow of blood through microcapillaries and thus cause tissue hypoxia, are not simply correlated with but in fact, by preceding it, may be a chief intermediary cause of POTS, in which tachycardia is simply the body’s exaggerated ‘physiological’ response to hypoxia.”
Postural orthostatic tachycardia syndrome (POTS) is a common accompaniment of a variety of chronic, inflammatory diseases, including long COVID, as are small, insoluble, ‘fibrinaloid’ microclots. We here develop the argument, with accompanying evidence, that fibrinaloid microclots, through their ability to block the flow of blood through microcapillaries and thus cause tissue hypoxia, are not simply correlated with but in fact, by preceding it, may be a chief intermediary cause of POTS, in which tachycardia is simply the body’s exaggerated ‘physiological’ response to hypoxia. Similar reasoning accounts for the symptoms bundled under the term ‘fatigue’. Amyloids are known to be membrane disruptors, and when their targets are nerve membranes, this can explain neurotoxicity and hence the autonomic nervous system dysfunction that contributes to POTS. Taken together as a system view, we indicate that fibrinaloid microclots can serve to link POTS and fatigue in long COVID in a manner that is at once both mechanistic and explanatory. This has clear implications for the treatment of such diseases.
R.L. LE
N-gated Hacker News
Hacker News
Zoomers of the Sunshine Coast 🇨🇦
Denis - The COVID info guy -
trendless
CurrentBias
Caramelized Shallots
Emily Johnson