Microbiome-produced nicotinic acid controls colon regional identity & injury susceptibility.
The #microbiome shapes proximal #colon identity via nicotinic acid–Pparα signaling, protects against injury & loses this regionalization in disease.
https://www.sciencedirect.com/science/article/pii/S0092867426001728 #intestine
The article describes how aging-related changes in the gut microbiome can influence brain signaling through the vagus nerve, leading to memory decline, and how altering gut bacteria or stimulating gut-brain pathways can restore memory in aging mice. It also identifies a specific bacterium, Parabacteroides goldsteinii, whose byproducts trigger local gut inflammation that impairs memory, and discusses potential translating approaches and remaining questions for humans.
The topic highlights how peripheral body processes interact with brain function, offering insights into mechanisms of cognitive aging. It also illustrates how interventions targeting the gut or gut-brain communication could modulate memory, underscoring the interconnectedness of physiological systems in psychology.
Article Title: Scientists discover how gut inflammation can drive age-associated memory loss
Link to PsyPost Article: https://www.psypost dot org/scientists-discover-how-gut-inflammation-can-drive-age-associated-memory-loss/
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Looking forward to giving a plenary lecture at the VAAM 2026 conference in Berlin (my talk is on Sunday)
It's on my favorite topic....
I hit a professional milestone today with my first senior author research manuscript getting published. So much work from so many awesome people over the past five years, but it's finally out in the world. Have a read #microbiome #cdifficile #fiber
https://www.cell.com/iscience/fulltext/S2589-0042(26)00633-4
For those seeking natural digestive support: Including ginger in daily meals may help stimulate digestion, reduce bloating, and support metabolic function. A gentle, plant-based way to optimize your body's systems! ✨🌿
Hidden Gut Bacteria CAG-170
As a medical school professor, I've spent decades studying the gut microbiome. But we've been missing something enormous.
Scientists just discovered a "hidden" group of gut bacteria -- CAG-170 -- that may be the single best marker of human health.
The findings are remarkable:
-> 11,000+ people across 39 countries
-> 13 different diseases studied
-> Healthy people consistentl...
https://www.cam.ac.uk/research/news/hidden-bugs-in-our-gut-appear-key-to-good-health-finds-global-study
#GutHealth #Microbiome #MetabolicHealth #Longevity #Prevention
13-Mar-2026
Microbial clues uncover how wild #songbirds respond to #stress
Researchers studied wild Northern cardinals to see how everyday challenges shape the gut microbiome. Even brief disruptions, like short handling or rival interactions, triggered microbial changes linked to stress hormones, body condition and beak coloration. Birds with the largest microbial shifts also showed pronounced physiological and visual stress responses, highlighting the gut microbiome as a sensitive indicator of health. The study reveals how subtle, routine stressors influence internal biology, offering new insights into how wild animals maintain resilience and cope with environmental pressures.
As a medical school professor, I never imagined I'd say this: an antibiotic might slow aging.
HHMI researchers discovered that tiny doses of cephaloridine turn gut E. coli into factories that pump out colanic acid -- a compound proven to extend lifespan.
In worms: lifespan extended up to 30%.
In mice: better cholesterol, lower insulin, reduced gut permeability, less inflammation.
The key? Cephaloridine i... https://www.sciencedaily.com/releases/2026/01/260131085024.htm
#GutHealth #Longevity #Microbiome #AntiAging #MetabolicHealth
Biohacking Pathway
David Ojcius
Psychotherapy Commission ACPE
Matthias C. Rillig
Giuseppe Michieli
Hazletok
Heal City
Robert Lufkin MD
michael