A Rogue New Life Form

A tiny microbe discovered by accident challenges the definition of cellular life

Nautilus
#Archaea sometimes turn against #Bacteria using hitherto unknown mechanisms. This Primer explores a @PLOSBiology study that reveals bacterium-killing peptidoglycan hydrolases in archaea. Paper: https://plos.io/4lrJBBa Primer: https://plos.io/3HGMYpU
Antimicrobials produced by archaea can kill bacteria

As bacteria become increasingly resistant to antibiotics and other antibacterials, there is a growing need for alternatives. In a study published in the open-access journal PLOS Biology, Tobias Warnecke and colleagues from the University of Oxford and the MRC Laboratory of Medical Sciences, United Kingdom, identified untapped antimicrobials produced by archaea, single-celled organisms that make up one of the three domains of life (the other two being bacteria and eukaryotes, the group that includes us).

Phys.org
Archaea-on-bacteria action! This study shows that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @PLOSBiology https://plos.io/4lrJBBa
In this #paper, we looked at how the 3D #structure of an #enzyme may change through #adaptation to different thermal environments over millions of years. Specifically, we compared 70 adenylate kinases of #bacteria and #archaea, from extreme cold-loving #species to extreme heat-loving ones. 🧵2/7

Hmm. 79C GPU temperature during r10 methylation & basecalling. Background lab temperature is about 90~93F (32~34C) so the makeshift ventilation & cooling solution for the workstation is working surprisingly well.

One more sequencing run until I have a full gamut of the target #Archaea species. Woot!

Sukunaarchaeum mirabile: What Constitutes a Cellular Life?  
Researchers have discovered a novel archaeon in symbiotic relationship in amarine microbial system that displays an extreme genome reduction in...........
#archaea #biology #Cell #CellularLife #Genome #Life #science #Sukunaarchaeummirabile #virus
Kamakhya P. Seal

https://www.scientificeuropean.co.uk/sciences/biology/sukunaarchaeum-mirabile-what-constitutes-a-cellular-life/

Sukunaarchaeum mirabile: What Constitutes a Cellular Life?  
Researchers have discovered a novel archaeon in symbiotic relationship in amarine microbial system that displays an extreme genome reduction in...........
#archaea #biology #Cell #CellularLife #Genome #Life #science #Sukunaarchaeummirabile #virus
Kamakhya P. Seal

https://www.scientificeuropean.co.uk/sciences/biology/sukunaarchaeum-mirabile-what-constitutes-a-cellular-life/

New #ISEPpapers! Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases https://onlinelibrary.wiley.com/doi/10.1111/tra.70016 by Anna Novák Vanclová et al.

#Protists #Microbes #Archaea #Eukaryogenesis #Evolution #Eukaryotes

Minimod preprint from @hasindu2008 gang is out. Code available https://github.com/warp9seq/minimod

I love the work they're doing with slow5/blow5 open spec for ONT raw data, and archive all internal reads using them. Really need to sit down and test this one out with my #archaea raw data!

#bioinformatics #methylation #ONT #sequencing

GitHub - warp9seq/minimod: A bioinformatics tool for viewing and calculating base modification frequencies from BAM files

A bioinformatics tool for viewing and calculating base modification frequencies from BAM files - warp9seq/minimod

GitHub