🚀 What if we could precisely target the CAPON–nNOS axis — a pathway long considered undruggable?

🔗 Targeting CAPON to modulate the CAPON–NOS Axis: a computational approach. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.001

📚 CSBJ: https://www.csbj.org/

#DrugDiscovery #ComputationalBiology #AlzheimersResearch #Neuroscience #ProteinProteinInteractions #VirtualScreening #MolecularDynamics #AIinDrugDiscovery

🔬 Can structural shifts at the atomic level decide treatment outcomes in AML?

🔗 Understanding the characteristic behaviour of the wild-type and mutant structure of FLT3 protein by computational methods. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.023

📚 CSBJ: https://www.csbj.org/

#ComputationalBiology #MolecularDynamics #StructuralBiology #CancerResearch #AML #DrugDiscovery #PrecisionMedicine #KinaseResearch #Bioinformatics

🧬 How did changes at the atomic scale reshape viral infectivity?

🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034

📚 CSBJ: https://www.csbj.org/

#COVID19 #SARSCoV2 #SpikeProtein #ACE2 #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology

🧩 Could structural AI finally decode the complex language of T-cell antigen recognition?

🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ProteinLanguageModels #Immunotherapy #ComputationalBiology #Bioinformatics #MachineLearning #Immunology #ProteinEngineering #TCR #HLA #DrugDiscovery #AI

Job Alert

Scientist in Computational Biology  

Deadline: 2025-12-20  
Location: Germany, Heidelberg

https://www.academiceurope.com/ads/scientist-in-computational-biology/

#CancerResearch #ComputationalBiology #Medicine #Healthcare #bioinformatics #hiring

🧬 What new possibilities emerge when Large Language Models (LLMs) meet large-scale omics data?

🔗 Large language models and their applications in bioinformatics. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.031

📚 CSBJ: https://www.csbj.org/

#Bioinformatics #ArtificialIntelligence #LargeLanguageModels #ComputationalBiology #Genomics #Proteomics

✨ Is it time to rethink allosteric site prediction using internal protein nanoenvironments?

🔗 Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.036

📚 CSBJ: https://www.csbj.org/

#DrugDiscovery #ComputationalBiology #StructuralBiology #ProteinEngineering #Biophysics #Cheminformatics

💊 Can understanding receptor bias help us design safer, more selective GPCR drugs?

🔗 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.039

📚 CSBJ: https://www.csbj.org/

#GPCR #StructuralBiology #MolecularDynamics #NMR #Pharmacology #ProteinStructure #DrugDiscovery #ComputationalBiology #CellSignaling

🧬 Ever wondered how the genome actually looks when it folds inside the nucleus — and how fast we can simulate it?

🔗 Multiscale molecular modeling of chromatin with MultiMM: From nucleosomes to the whole genome. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.025

📚 CSBJ: https://www.csbj.org/

#ChromatinModeling #3DGenome #ComputationalBiology #Genomics #MolecularModeling #GenomeArchitecture #ChromatinStructure #HiC #ATACSeq #Biophysics #StructuralBiology