π° "Wolbachia-induced Cytoplasmic Incompatibility drives epigenetic and maternally-influenced post-embryonic defects"
https://www.biorxiv.org/content/10.64898/2026.04.15.718768v1?rss=1 #Gastrulation #Drosophila #Embryo #Larvaπ° "Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila"
https://doi.org/doi:10.1093/nar/gkag294https://pubmed.ncbi.nlm.nih.gov/41978263/ #Drosophila #Embryo #Larvaπ° "Independent roles of autophagy and apoptosis in post-apocrine-secretion cell death of salivary glands during Drosophila metamorphosis"
https://doi.org/doi:10.1038/s41598-026-46472-3https://pubmed.ncbi.nlm.nih.gov/41965915/ #Drosophila #Larvaπ° "The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in drosophila"
https://doi.org/doi:10.1242/jcs.264770https://pubmed.ncbi.nlm.nih.gov/41958408/ #Drosophila #Sensory #Larva
The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in drosophila
Neurite and synapse pruning are conserved mechanisms that adapt neuronal circuitry to different developmental stages. Drosophila sensory c4da neurons prune their larval dendrites and their presynaptic terminals during metamorphosis using a gene expression programme that is induced by the steroid hormone ecdysone and involves posttranscriptional regulation pathways. Here we show that loss of the helicase UAP56, an important mediator of nuclear mRNA export, causes strong dendrite and presynapse pruning defects. Loss of UAP56 is linked to actin regulation, as it causes defects in the ecdysone-induced expression of the actin severing enzyme Mical during metamorphosis and actin accumulation at pruning presynapses. In support of an important role of actin regulation during presynaptic pruning, we find that cofilin is required for this process. Our findings highlight the role of posttranscriptional regulation in neuronal remodeling and identify an actin disassembly factor required for presynapse pruning.
Ring canals in the larval adipose of Drosophila buffer stress response
Whether and how individual cells within a tissue cooperate with each other to respond to cellular stress has remained elusive. Nandakumar et al. show that
Neuropeptidergic circuit modulation of developmental sleep in Drosophila
Different impacts of the same molecular and circuit mechanisms on sleepβwakefulness control in early-life juveniles and adults.
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