When technology meets mathematics: The A100 GPU powers the discovery of the latest giant in the prime number world! 🚀💻✨🔍💡🧮💥🎉
The "new" largest prime was discovered today (October 21, 2024)! It's a Mersenne prime \( (2^p-1 )\), which is easier to find because it can utilize a specialized "faster" primality test (known as LLT, i.e., Lucas-Lehmer test). On October 11, an NVIDIA A100 GPU in Dublin, Ireland, reported that M136279841 is probably prime. On October 12, an NVIDIA H100 in San Antonio, Texas, USA, confirmed primality with a Lucas-Lehmer test.
\[\Huge 2^{136,279,841}-1\]
It took nearly 6 years for the Great Internet Mersenne Prime Search (GIMPS )software to find it after the previous largest known prime. It was also the first Mersenne prime found using GPUs.
#Prime #PrimeNumber #LargestPrime #LargestKnownPrime #MersennePrimeA100 #TensorCore #LLT #LucasLehmerTest #PrimalityTest #GPGPUs #GIMPS
https://www.mersenne.org/primes/?press=M136279841
https://www.livescience.com/physics-mathematics/mathematics/largest-known-prime-number-spanning-41-million-digits-discovered-by-amateur-mathematician-using-free-software
https://www.popularmechanics.com/science/math/a62695223/biggest-prime-number/
https://www.popsci.com/science/largest-prime-number/
https://www.smithsonianmag.com/smart-news/amateur-mathematician-discovers-the-largest-known-prime-number-with-more-than-41-million-digits-180985321/
https://www.newscientist.com/article/2452686-amateur-sleuth-finds-largest-known-prime-number-with-41-million-digits/
https://www.sciencefocus.com/news/new-prime-number
https://sherwood.news/culture/new-largest-prime-number-discovered-by-former-nvidia-software-engineer/
https://www.tomshardware.com/tech-industry/former-nvidia-engineer-discovers-41-million-digit-prime-largest-prime-number-known-to-man-was-uncovered-and-verified-with-the-help-of-gpus
https://www.washingtonpost.com/science/2024/10/23/nvidia-prime-mersenne-gpu-cloud/
https://gizmodo.com/nvidia-computer-finds-largest-known-prime-blows-past-record-by-16-million-digits-2000514948
https://fermatslibrary.com/p/6883b84b
https://en.wikipedia.org/wiki/Lucas%E2%80%93Lehmer_primality_test
https://en.wikipedia.org/wiki/Great_Internet_Mersenne_Prime_Search
https://en.wikipedia.org/wiki/Probable_prime
https://en.wikipedia.org/wiki/Largest_known_prime_number
Statin revisited.
❤️🔥 statin vs no-statin: 25% RRR MACE
❤️🔥 intense statin vs less intensive: addl 15% RRR
❤️🔥 high intensity statin w/⬇️50mg/dL achieved = 28% RRR MACE
3/ #llt
trying to understand why another provider told a young MI <55 yrs of age pt to stop their statin+eze and “just go with repatha, because it works better”.
Fourier and Odyssey were incremental add-on tx to baseline statin, ADDing RRR of 15%. https://link.springer.com/article/10.1007/s40119-020-00163-w #llt
For more than half a century, low-density lipoprotein cholesterol (LDL-C) has been recognized as a major risk factor for incident atherosclerotic cardiovascular disease. The discovery of proprotein convertase subtilisin-kexin type 9 (PCSK9) in 2003, which prevents LDL-C receptor recycling, identified a new target for drug intervention. Recently, two large-scale randomized clinical outcomes trials involving fully human anti-PCSK9 monoclonal antibodies tested the hypothesis that targeting this pathway would reduce cardiovascular events. Both the FOURIER (Further cardiovascular OUtcomes Research with PCSK9 Inhibition in subjects with Elevated Risk) and ODYSSEY OUTCOMES trials met their primary efficacy endpoints, confirming findings reported earlier that major adverse cardiovascular events can be reduced by a further lowering of LDL-C beyond that achieved with statin therapy. In both trials, there were incremental reductions in LDL-C of > 50% from baseline, with no major safety concerns, over the trials’ median follow-up time (2.2 and 2.8 years, respectively). While there were differences in design, lipid management and overall results, key messages from both studies were similar. However, post-publication, additional questions have arisen, especially regarding drug effects over the long-term, including a potential mortality benefit.
Mr. C
RisingEdge 🏳️🌈
Pustam | पुस्तम | পুস্তম🇳🇵
nope
Viet Le, MPAS PA-C FACC FAHA
