High Fat Diet Activates Early Inflammation in Mouse Brains, Supports Link to Neurological Disease

High-fat diets promote early inflammatory responses in the brain via an immune pathway associated with diabetes and neurodegenerative diseases. The findings suggest a link between metabolic dysfunction and cognitive impairment.

#Neuroscience #Neurology #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Inflammation #Metabolism #MetabolicDysfunction #Diabetes #Alzheimer #CognitiveImpairment #Diet #HighFatDiet

https://neurosciencenews.com/high-fat-diet-inflammation-neurodegeneration-22275/

Did you know that starting a high-fat #diet causes an adaptation of the #intestinal #epithelium within only 24 hours?

In this interesting study, Jacob Enriquez and colleagues at Cincinnati Children's Hospital Medical Center used physiological metrics and single-cell transcriptomics to interrogate the intestinal epithelial cell response to a high-fat diet in mice.

Article in Cell Reports: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01512-1

#highfatdiet #lipidmetabolism #nutrition #differentiation #epigenetics