Attachment and #replication of clade 2.3.4.4b #influenza #H5N1 viruses in #human respiratory #epithelium: an in-vitro study

The experiments were dramatic, here are the
spectacular simulations by Marino's team.

#tissue #epithelium #buckling #shell #elasticity #biophysics #biomechanics

@Rxiv_mechanobio

Variable #DPP4 #expression in multiciliated cells of the #human #nasal #epithelium as a determinant for #MERS-CoV tropism, https://etidiohnew.blogspot.com/2025/03/variable-dpp4-expression-in.html
Variable #DPP4 #expression in multiciliated cells of the #human #nasal #epithelium as a determinant for #MERS-CoV tropism

A 2022 avian #H5N1 #influenza A virus from clade 2.3.4.4b attaches to and replicates better in #human respiratory #epithelium than a 2005 H5N1 virus from clade 2.3.2.1

Source: BioRxIV, AbstractBackground: Highly pathogenic avian influenza (HPAI) H5 viruses of the A/Goose/Guangdong/1/1996 (GsGd) lineage pose significant global risks to wildlife, domestic animals, and humans. Recent cross-species transmission events to mammals, including humans, highlight this risk.…

https://etidioh.wordpress.com/2024/11/28/a-2022-avian-h5n1-influenza-a-virus-from-clade-2-3-4-4b-attaches-to-and-replicates-better-in-human-respiratory-epithelium-than-a-2005-h5n1-virus-from-clade-2-3-2-1/

A 2022 avian #H5N1 #influenza A virus from clade 2.3.4.4b attaches to and replicates better in #human respiratory #epithelium than a 2005 H5N1 virus from clade 2.3.2.1

Source: BioRxIV, AbstractBackground: Highly pathogenic avian influenza (HPAI) H5 viruses of the A/Goose/Guangdong/1/1996 (GsGd) lineage pose significant global risks to wildlife, domestic animals, …

ETIDIoH
Study pinpoints cellular response to pressure in sea star embryos

An international team of scientists has discovered a new cellular mechanism that explains how cells can adapt to pressure changes during tissue growth by packing themselves into a unique shape.

Phys.org
A Skin-Deep Wound Can Trigger Gut Bacteria Changes

Damage to the skin isn't always just surface-level.

ScienceAlert

@preLights
And we also had a variant of your pathway C of #epithelial fold formation : folding by *tensile* mechanical #buckling

(Note: these are my hands on the photo, so technically this is my own's only and single published experiment!)

#epithelium

A different origami-guide: Irreversible folds in morphogenesis 🔰

Teodora Piskova #RWTH covers work from the #MechgenLab

“…this #preprint seeks to explain how certain material behaviors of tissues matter for fundamental processes such as #morphogenesis…”

#preLight 👉 https://prelights.biologists.com/highlights/elasto-plastic-transition-in-epithelial-folding-v2/

#biomechanics #development #epithelium #mechanobiology #mechanosensing

Elasto-Plastic Transition in Epithelial Folding - preLights

A different origami-guide: Irreversible folds in morphogenesis

preLights
Cells in confinement and people in crowds have similar behaviors, shows study

On a rush-hour train or a crowded flight, you might draw your limbs in close, shrinking as people fill the space. As it turns out, living cells behave similarly in confinement, adjusting their size while growing alongside other cells in sheets of tissue.

Phys.org
The UMR996 lab (Inserm/Paris-Saclay shorturl.at/crxDZ) has a job opening (Inserm Chair position) in SKIN #IMMUNOSURVEILLANCE IN RELATION WITH COMMENSAL
#VIROME. shorturl.at/ghOT8 #epithelium #HPV