Joseph P.

@tonic@mstdn.science
17 Followers
840 Following
293 Posts
I'm playing my part to support #biomanufacturing #biofabrication #biofoundry(ies) and bear witness to the birth of an industry. Working with 2 novel compounds to grow bone, cartilage & other types of cells. Turns out they also work for growing hearts @organamet.
Med@tonic
Personal@tonic
Twitterhttps://twitter.com/josephpollack/
Joseph P.Feb 17, 2023
Laura HowesFeb 17, 2023
Here's a first... I just got an email because ChatGPT suggested an article I wrote to somebody. Could I send them a copy? Except, I never wrote the article, it doesn't exist. PLEASE realize right now that this tool isn't pulling out cool references for you. It's making plausible titles and matching them to authors names.
Joseph P.Dec 28, 2022
Robert “The Bobby Yaga” McNeesDec 28, 2022

A team led by physicist Chien-Shiung Wu obtained the first experimental confirmation of parity violation in the decay of Cobalt-60, #OTD in 1956.

Her theory colleagues received a Nobel for predicting this phenomenon, but she was left off the prize.

Image: Smithsonian Institution Archives

Joseph P.Dec 23, 2022
Show threadSuzanne van der LaanDec 23, 2022
@tonic Thank you very much for this explanation. I do believe this is also interesting for metabolic diseases. Mabe it is to early now, but i wil keep it in mind.
Joseph P.Dec 21, 2022
Show threadJack Iwashyna 🫁Dec 21, 2022

"The software is designed to build a record of care that can be translated into billing codes, and this sometimes diverges from the reali- ties of clinical care.29 Several of our respondents voiced the concern that there could be unintended consequences or biased analyses if precision medicine researchers fail to adequately recognize

that much of #EHR data is #BillingData, not #ClinicalData"

Can we bold that, please?

Joseph P.Dec 21, 2022
Patrick MacDonaldDec 21, 2022

A great paper from @annagloyn and colleagues! Happy we were able to contribute.

"A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk" Nature Genetics.

https://t.co/wD8SreMFzQ

Joseph P.Dec 20, 2022
Ridge SligerDec 20, 2022
Give a man a fish, and he’ll eat for a day.
Teach a man to fish, and he’ll eat for a lifetime.
Teach a man to be a fish biologist, and he’ll have an increasingly difficult relationship with eating fish, as he navigates the difficulties of a complex conservation landscape, attempting to avoid, not only starvation, but the over-exploitation of sensitive populations and the harmful health effects of the likes of PCB, PFAs, and mercury pollution.
Show threadJoseph P.Dec 19, 2022

Other roles for mitochondrial dynamics proteins in the #heart include helping to move #calcium into the mitochondria and regulating the structure of the mitochondria.

#Mitochondria are organelles in cells that are responsible for producing #energy. They can change their structure by breaking apart (#fission) and reforming (#fusion). This process is complicated and energy intensive, so it is important to understand why it is necessary.

Show threadJoseph P.Dec 19, 2022
This movement is important for maintaining the stability of the mitochondrial #DNA, which is the genetic material found in mitochondria, and for controlling the cell's #respiration. It can also be involved in programmed #CellDeath. In the #heart, mitochondrial dynamics #protein s, such as #mitofusin s, optic #atrophy, and dynamin-related protein, are highly expressed and play an important role in maintaining the quality of the #mitochondria.
Joseph P.Dec 19, 2022

How Mitochondrial Dynamism Orchestrates Mitophagy

Orian S. Shirihai, Moshi Song, Gerald W. Dorn II

#explainpaper @explainpaper

Understanding the Significance of Mitochondrial Fission and Fusion

Mitochondrial dynamics refers to the movement of #mitochondria within a cell. This includes #fission, which is when mitochondria divide into two parts, #fusion, which is when two mitochondria join together, and #translocation, which is when mitochondria move from one part of the #cell to another.

Joseph P.Dec 14, 2022
Biology OpenDec 14, 2022

In this Research Article, Marjan Abbasi et al. identify two #phosphosites in the #yeast spindle pole body protein Spc110 that regulate timely cell cycle progression:

https://journals.biologists.com/bio/article/11/11/bio059565/280976

Find out more about the story behind the paper in this interview with first author Marjan, who is a PhD student in the lab of Victoria Menendez-Benito at the Karolinska Institutet, Stockholm, Sweden:

https://journals.biologists.com/bio/article/11/11/bio059713/281165

#Centrosome #SPB #CellScience #Biology #Science #CellCycle #Research #BiologyOpen

Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit

Summary: We identified two phosphosites (S11 and S36) in the yeast centrosome component Spc110 from maternal origin and found that these phosphosites control timely cell cycle progression.

The Company of Biologists