#NKcells #Innateimmunity #CatDad
Views are my own
| Website | www.osullivanlab.com |
O'Sullivan Lab
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- 20 Posts
Assistant Professor #UCLA
#NKcells #Innateimmunity #CatDad
Views are my own
#NKcells #Innateimmunity #CatDad
Views are my own
Check out our papers recent highlight and some of our commentary with Salon.com
We have recently found that #NK cell effector function is sexually dimorphic. How? Female NK cells in mice and human express higher levels of the epigenetic regulator #UTX, which escapes X-linked inactivation. UTX regulates the chromatin accessibility of #IFNg and #Csf2, making female NK cells more potent in response to #cytokines and #viral infection.
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences - Nature Immunology
Cheng et al. demonstrate that an extra copy of the X-linked epigenetic regulator UTX in females increases natural killer (NK) cell effector function. As NK cells are critical for antiviral immunity, this may explain decreased severity of viral infections in females compared to males.
Thiago Carvalho"Here, we have identified a population of innate lymphocytes that we term tissue-resident memory-like natural killer (NKRM) cells. In response to murine cytomegalovirus infection, we show that circulating NK cells were recruited in a CX3CR1-dependent manner to the salivary glands where they formed NKRM cells, a long-lived, tissue-resident population that prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells."
Schuster et al @ImmunityCP
#Immunology #NKCells #ImmuneRegulation
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
halama_immunoProtecting #tissues from #autoimmunity is a fascinating function of the immune system: in this new work on #innateimmunity in the salivary gland it is #lymphoid #NKcells that regulate #TCells and prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells. These NK cells show adaptive-like features with long-term residency in non-lymphoid tissues. #immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
We now know that circulating #NK cells can become tissue-resident following infection. Function is to limit #autoimmunity through #TRAIL mediated elimination of CD4+ T cells in sites of viral persistence. Team science is the best science!
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
Isabella RauchI am Co-PI on a grant, a reviewer said "need to include an expert in enteric pathogens and immune responses"
So 14 papers with intestinal epithelial or inflammation models, 7 of which use Shigella/Salmonella/Citrobacter not enough?
Or is it my lack of a Y chromosome/grey hair? 🤬
So 14 papers with intestinal epithelial or inflammation models, 7 of which use Shigella/Salmonella/Citrobacter not enough?
Or is it my lack of a Y chromosome/grey hair? 🤬
Happy to collaborate on this study profiling the existence and development of cross-tissue #ILC1 in humans.
https://doi.org/10.1016/j.celrep.2022.111937
Key Takeaways:
-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers.
-Unknown #LSEC-derived signals + #TGFβ1 + #il7 drive differentiation of ILC progenitors to ILC1.
-Human #NK cells do not differentiate to ILC1 under multiple conditions ex vivo.
-Human ILC1 make #il2 but functional relevance of this still unknown.
Greg KohnPretty convincing article on peer review. One thought, I don’t know if we (‘we’ being the science world collectively) know how to communicate to the public that some “research” is engineered to be biased (think AEI, CATO reports, contract research) while others are independent. Peer review has given independent researchers a powerful tool to limit the influence of special interests. https://experimentalhistory.substack.com/p/the-rise-and-fall-of-peer-review
