David Ojcius“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”
#inflammation #mycology #microbiology #immunity #immunology #innateimmunity
https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd
halama_immunoNew publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to #immunotherapy is observed. These findings are then put into action for patient stratification, showing the utility in #radiology and #medicaloncology and #oncology #Science #medicine #immunology
mymedschoolLearn about phagocyte dysfunction immunodeficiencies, including CGD, LAD, and Chediak-Higashi syndrome, their mechanisms, and clinical relevance. #Immunodeficiency #PhagocyteDysfunction #CGD #LAD #ChediakHigashi #Immunology #MedicalEducation #USMLE #Pathology #InnateImmunity #NeutrophilDefects
Leukocyte Adhesion Deficiency (LAD Type 1): Delayed Umbilical Cord Separation & Recurrent Infections | USMLE Immunology
Learn how to identify Leukocyte Adhesion Deficiency Type 1 (LAD-1) on USMLE-style questions. Understand the hallmark features — delayed cord separation, recurrent bacterial infections without pus, and CD18 deficiency — with diagnostic reasoning and high-yield immunology insights.
CITO GreenhouseThe Tiny Warriors of Your Immune System: How Our Body Fights Infections
#ImmuneSystem #VaccineScience #SpikeProteins #Antibodies #InnateImmunity #AdaptiveImmunity #StressAndHealth #CytokineStorm #GutHealth #MentalHealthAndImmunity #HealthAwareness #ImmunityBoost #WellnessTips #MedicalScience #StayHealthy
PLOS BiologyCytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe
#InnateImmunity is a crucial surveillance framework. However, @Colombani explores 2 @PLOSBiology studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth. Papers: https://plos.io/4jqpmUh https://plos.io/3RGWESS Primer: https://plos.io/3GyUeU0
Activation of the Drosophila innate immune system accelerates growth in cooperation with oncogenic Ras
Innate immune signaling acts as a surveillance system to fight potential infections, but it can become overactivated in malignant cells. These authors show that the tissue-protective functions of innate immune signaling involving oncogenic Ras can be misused by premalignant cells in Drosophila to induce overgrowth in the initial stages of tumor development.
David GregoryNew study! Learning about inflammation by studying the differences between mammals – a toot-orial.
https://doi.org/10.1186/s10020-024-01052-x
When the body meets an infectious microbe or similar challenge it activates an inflammatory cascade. Inflammation helps eliminate the microbe, but, if it gets of control, it can be dangerous or even fatal.
We like to assume that inflammation is basically the same for all animals. And this is usually true in cell culture, but in vivo …
1/
Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation - Molecular Medicine
Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteomes and lipidomes. Unexpectedly, at baseline, sensitive species already had enhanced expression of LPS-responsive genes relative to resilient species. After LPS stimulation, maximally different genes in resilient species included genes that detoxify LPS, diminish bacterial growth, discriminate sepsis from SIRS, and play roles in autophagy and apoptosis. The findings reveal the molecular landscape of species differences in inflammation. This may inform better selection of species for pre-clinical models and could lead to new therapeutic strategies that mimic mechanisms in inflammation-resilient species to limit inflammation without causing immunosuppression.
@cyrilpedia Together with the organ-specific composition of the #innateimmunity cellular mix, there is still a vast landscape that needs our attention. Why does the dynamic of #autoimmunity or #antitumoral show such a great organ-specific diversity...? And not only on the T cell repertoire... @gpollara @scholpp_lab
Thiago Carvalho'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor
'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1