Happy to collaborate on this study profiling the existence and development of cross-tissue #ILC1 in humans.

https://doi.org/10.1016/j.celrep.2022.111937

Key Takeaways:

-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers.

-Unknown #LSEC-derived signals + #TGFβ1 + #il7 drive differentiation of ILC progenitors to ILC1.

-Human #NK cells do not differentiate to ILC1 under multiple conditions ex vivo.

-Human ILC1 make #il2 but functional relevance of this still unknown.