#NKcells #Innateimmunity #CatDad
Views are my own
| Website | www.osullivanlab.com |
O'Sullivan Lab
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Assistant Professor #UCLA
#NKcells #Innateimmunity #CatDad
Views are my own
#NKcells #Innateimmunity #CatDad
Views are my own
We have recently found that #NK cell effector function is sexually dimorphic. How? Female NK cells in mice and human express higher levels of the epigenetic regulator #UTX, which escapes X-linked inactivation. UTX regulates the chromatin accessibility of #IFNg and #Csf2, making female NK cells more potent in response to #cytokines and #viral infection.
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences - Nature Immunology
Cheng et al. demonstrate that an extra copy of the X-linked epigenetic regulator UTX in females increases natural killer (NK) cell effector function. As NK cells are critical for antiviral immunity, this may explain decreased severity of viral infections in females compared to males.
Happy to collaborate on this study profiling the existence and development of cross-tissue #ILC1 in humans.
https://doi.org/10.1016/j.celrep.2022.111937
Key Takeaways:
-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers.
-Unknown #LSEC-derived signals + #TGFβ1 + #il7 drive differentiation of ILC progenitors to ILC1.
-Human #NK cells do not differentiate to ILC1 under multiple conditions ex vivo.
-Human ILC1 make #il2 but functional relevance of this still unknown.
A big congrats to Dr. Andrew Hildreth on passing his thesis defense! #PhDone
Cloud thanks you for the recent connections! Stay tuned for more #cat and #science content. #Cloudodon