#NKcells #Innateimmunity #CatDad
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O'Sullivan Lab
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Assistant Professor #UCLA
#NKcells #Innateimmunity #CatDad
Views are my own
#NKcells #Innateimmunity #CatDad
Views are my own
Check out our papers recent highlight and some of our commentary with Salon.com
@gpollara @ImmunologyKing Very interesting!
@ImmunologyKing Thank you! I also saw a talk about sexual dimorphism in ILC2 responses, so wouldn't be surprised to see this in ILC3s as well.
We have recently found that #NK cell effector function is sexually dimorphic. How? Female NK cells in mice and human express higher levels of the epigenetic regulator #UTX, which escapes X-linked inactivation. UTX regulates the chromatin accessibility of #IFNg and #Csf2, making female NK cells more potent in response to #cytokines and #viral infection.
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences - Nature Immunology
Cheng et al. demonstrate that an extra copy of the X-linked epigenetic regulator UTX in females increases natural killer (NK) cell effector function. As NK cells are critical for antiviral immunity, this may explain decreased severity of viral infections in females compared to males.
Thiago Carvalho"Here, we have identified a population of innate lymphocytes that we term tissue-resident memory-like natural killer (NKRM) cells. In response to murine cytomegalovirus infection, we show that circulating NK cells were recruited in a CX3CR1-dependent manner to the salivary glands where they formed NKRM cells, a long-lived, tissue-resident population that prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells."
Schuster et al @ImmunityCP
#Immunology #NKCells #ImmuneRegulation
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
@ImmunologyKing @halama_immuno Yes likely context dependent signals in different tissues. RAG2-/- mice still have NK cells with similar phenotype in adipose. Important not to confuse these with ILC1 though.
@ImmunologyKing @halama_immuno We also find similar cells in human liver and adipose, how do they get there??
halama_immunoProtecting #tissues from #autoimmunity is a fascinating function of the immune system: in this new work on #innateimmunity in the salivary gland it is #lymphoid #NKcells that regulate #TCells and prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells. These NK cells show adaptive-like features with long-term residency in non-lymphoid tissues. #immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2