Randall Schirra 

@Schiracha@mstdn.science
3 Followers
240 Following
149 Posts
#Introduction I am a postdoctoral scientist working on Cryo-ET image processing in the Carazo Lab in Madrid @CNB_CSIC. We develop new methodologies to push cryo-ET to the stars #teamtomo #CryoEM #StructuralBiology
Easily the best picture I took in 2022.
Missing this little nugget while she is at the grandparents' for a week. #girldad #fatherhood #memories

Was @Klausenhauser, then @Klausenhauser now finally @klausenhauser here on struct.bio
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#introduction
Hi ’m also @klausenhauser over at Twitter. Let’s see how this new network turns out. Will it be the new Tiktok or Google Circles?

Here for the latest science, angry hot takes, cats, lab life and academia with a focus on all things structural and biophysical, with a dash of flowers, food, politics, and urban dev.

I attach the main figure for our report. As HIV-1 approaches the cell host membrane, the envelope glycoprotein binds initially just 1 CD4 receptor molecule, then 2 and finally 3 CD4 receptor molecules as it moves closer to the cell membrane. Fascinating for us to see that asymmetric Env trimers bound to 1 and 2 CD4 receptor molecules are readily observed by cryo-electron tomography.
I switched to the Tusky App and just realized how much I was missing out in the old app I used. It had a very minimalistic interface. I did not realize you could, in fact, follow hashtags and I had resorted to following a bunch of mostly dead a.gup.pe groups instead but adding many hashtags has certainly made the 🐘 feel more open than before. More 🐦 like but less noise
@MitosisLab is the first user I've seen linking to #OpenAccess #CryoEM data their lab shares. Check them out if you haven't, esp #TeamTomo

We have new paper in @BiophysicistJ about our
@strucbio TEACHING!

We have developed a semester-long learning path that integrate structure analysis using PyMOL in relevant biochemical context and support development of the students’ computational skills.

All science students benefit from some level of coding – We reasoned that structure analysis in PyMOL is a great lever for introducing python skills early as a few lines of code generate useful and stunning results.

https://doi.org/10.35459/tbp.2022.000219

Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL

ABSTRACT. Structural biology describes biological processes at the molecular level and is an integral part of undergraduate study programs in molecular biosciences. Students are often fascinated by the visualizations created by molecular graphics software, which allow them to see the molecular world for the first time. Today, molecular visualization and structural analysis do not require expensive high-end computers but can be performed on the students' own laptops and are therefore highly suited for active learning approaches. We have designed a semester-long learning path that integrates molecular graphics and structural analysis using PyMOL into an undergraduate course in biomolecular structure and function. Compared to stand-alone PyMOL introductions, the semester-long learning path allows for an improved pedagogical design. The path progressively introduces more advanced functions in relevant scientific contexts and allows for spaced repetition. Advanced analysis functions in PyMOL are available only via the command line, so the learning path also teaches basic scripting and serves as an accessible introduction to computational thinking because a few lines of code can produce stunning results. Student surveys carried out at the end of the course suggest that the learning path supported the ability to perform structural analysis to a high degree. Moreover, a simulated exam showed that almost all students were able to carry out basic visualization tasks using PyMOL scripts, while three-quarters could undertake advanced structural analysis after following the course. In summary, integration of molecular graphics software with teaching of structural biochemistry allows a hands-on approach to analyzing molecular mechanisms and introduces biologically oriented students to computational thinking.

Allen Press

You wouldn't know it, but I'm putting out this toot from an entirely different (hardware) server!

The backup and failover worked : )

@strucbio feel free to checkout struct.bio if you are interested, I'm going to open up the registration!

#CryoEM #StructuralBiology #xray #nmr

Postdoctoral Fellow - Ferguson Lab - Chemical Biology / Neurodegeneration @FleurMFerguson

The Ferguson Lab at UCSD is hiring a #postdoc in cell/molecular biology to work on projects combining #TPD and #NeurodegenerativeDisease research!

...
https://jobrxiv.org/job/university-of-california-san-diego-27778-postdoctoral-fellow-in-chemical-biology-neurodegenerative-disease-research/?feed_id=32870

Postdoctoral Fellow - Ferguson Lab - Chemical Biology / Neurodegeneration

We're keeping research funds for research. Find thousands of job offers like this one at jobRxiv!

jobRxiv

Over the past few years, we @mikrobiokosmos@twitter.com offer a 1-d workshop on scientific writing and publishing, mostly for MSc and PhD students. Here is a list of relevant material which we would like to expand, so please feel free to use it and also send me your suggestions/additions; please share/circulate.

https://sites.google.com/view/readingsonreadings/home

@academicchatter @phdstudents @phdlife #scicomm #AcademicMastodon 

Readings on scientific readings and review

ARTICLES Glass RL (2000) A letter from the frustrated author of a journal paper. Journal of Systems and Software 54:1 Burrows T (2011) Writing research articles for publication. Unpublished manuscript, the Asian Institute of Technology Language Center, Khlong Luang, Thailand. Kallestinova ED