RNA/cancer researcher
Assistant Professor
Department of Immunology and Cell Biology
@Université de Sherbrooke
Cancer Research Society SNGS scholar
https://mqvlab.com
#RNA #splicing #cancer #transcriptomics
If you wonder what splice isoforms exist for your gene(s) of interest, or if you are interested in exploring tissue/cancer-specific splicing, we have a new tool for that.
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad1043/7416386?login=false
Nouveau labo!
Je cherche des étudiant(e)s aux cycles supérieurs voulant travailler dans le domaine de l'épissage de l'ARN en #cancer et #immunologie.
New lab!
I'm looking for grad students interested in #RNAsplicing in #cancer and #immunology
Nous examinons les variations de l’ARN pour trouver de nouveaux traitments contre le cancer Notre labo utilise des données de séquençage à haut débit et des validations expérimentales pour trouver des variations de l’ARN impliquées dans le développement de tissus normaux et des cancers. En étudiant les variations d’épissage de l’ARN, il est possible de découvrir des signatures moléculaires ignorées par d’autres approches. Au cours des dernières années, l’analyse du transcriptome a permis d’apporter une lumière nouvelle sur des questions fondamentales dans les domaines des troubles du spectre de l’autisme et du cancer.
Climate Scientists Leave Twitter For Mastodon
So, it is possible for a group to make the collective decision to leave Twitter. Scientists "suffering insults and mass-spam are abandoning Twitter," and setting up shop on Mastodon.
Climate scientists flee Twitter as hostility surges >>> https://www.france24.com/en/live-news/20230524-climate-scientists-flee-twitter-as-hostility-surges
"Glaciologist @Ruth_Mottram had more than 10,000 followers on Twitter but left in February and joined an alternative scientists' forum powered by Mastodon."
1/
City of #Ljubljana in #Slovenia, population 280,000, kicked cars out in 2007.
Since then, car use has dropped by 32%, black carbon emissions are down 70%, noise pollution is down by 6 decibels.
Unfortunately, going car-free has made the center a living hell, as this video shows:
🧵
This week, Science published a stunningly irresponsible news story entitled "Fake scientific papers are alarmingly common" and claiming that upward of 30% of the scientific literature is fake.
https://www.science.org/content/article/fake-scientific-papers-are-alarmingly-common
Below, the first two paragraphs of the story.
Headline and intro notwithstanding, the story itself later notes that the detector doesn't actually work and flags nearly half of real papers as fake. Does the reporter just not understand that?
h/t @Hoch
Wow!
looks like super awesome method from Long Cai lab
"High-resolution spatial multi-omics reveals cell-type specific nuclear compartments"
They did mRNA #seqFISH+ (1200 genes, 17K introns), DNA seqFISH+ (100K loci) and #immunofluorescence (up to 65 antibodies) all in the same experiment!
200+ rounds of #imaging! That's incredible.
#mRNA #mRNALocalization #smFISH #DNA #3D_genome
#transcription #microscopy
Interested in riboswitches? The recording for our latest journal club is now available: https://youtu.be/d9TXI2tm5SI
Other topics ranging from RNA localization, stress granules, poly(A) and more are also available: https://irnacosi.org/journal-club/
I support the early career scientists in Canada who are walking out today to ask for their first pay raise in 20 years.
The federal government's track record in science has been on of neglect, and it's time to change that.
Reminder of our upcoming online journal club tomorrow, May 2 at 15:30GMT/11:30EDT/8:30PT.
We will be discussing RNA structural switches discovery with 1st author @khorms57
Register: https://pennmedicine.zoom.us/meeting/register/tJIscuiurTIpE9EDBk5Qour1gyweNlBMxyqp#/registration
@RNASociety
@iscb
"A systematic search for RNA structural switches across the human transcriptome" by Matvei Khoroshkin, postdoctoral fellow with Hani Goodarzi at UCSF Abstract: RNA structural switches are key regulators of gene expression in bacteria, yet their characterization in Metazoa remains limited. Here we present SwitchSeeker, a comprehensive computational and experimental approach for systematic identification of functional RNA structural switches. We applied SwitchSeeker to the human transcriptome and identified 245 putative RNA switches. To validate our approach, we characterized a previously unknown RNA switch in the 3’UTR of the RORC transcript. In vivo DMS-MaPseq, coupled with cryogenic electron microscopy, confirmed its existence as two alternative structural conformations. Furthermore, we used genome-scale CRISPR screens to identify trans factors that regulate gene expression through this RNA structural switch. We found that nonsense-mediated mRNA decay acts on this element in a conformation-specific manner. SwitchSeeker provides an unbiased, experimentally-driven method for discovering RNA structural switches that shape the eukaryotic gene expression landscape.
Our sister journals @Dev_journal
@J_Cell_Sci @J_Exp_Biol & @DMM_Journal offer Travelling Fellowships of up to £3,000 to #biology #PhD students & #Postdocs wishing to make collaborative visits to other laboratories.
Next application deadline is 5 May:
https://t.co/N44U3trodK
About Travelling Fellowships The Company of Biologists’ journals – Development, Journal of Cell Science, Journal of Experimental Biology and Disease Models & Mechanisms – offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. These are designed to offset the cost of travel/accommodation and other related expenses.[...] Read More
Mastodon Migration
𝚃𝚊𝚛𝚊𝚜 𝙶𝚛𝚎𝚜𝚌𝚘𝚎 🚇
Carl T. Bergstrom
Gal Haimovich 😷🔬☣🏳️🌈🏳️⚧
iRNA COSI
Zen Faulkes
Biology Open