Technical Assistant position – lncRNA localization regulation and function
Goethe University
See the full job description on jobRxiv: https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/
#cellbiology #noncodingRNAs #RNA #rnalocalization #RNAsplicing #ScienceJobs #hiring #research
https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/?fsp_sid=7039
Technical Assistant position – lncRNA localization regulation and function
Goethe University
See the full job description on jobRxiv: https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/
#cellbiology #noncodingRNAs #RNA #rnalocalization #RNAsplicing #ScienceJobs #hiring #research
https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/?fsp_sid=6703
Technical Assistant position – lncRNA localization regulation and function
Goethe University
See the full job description on jobRxiv: https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/
#cellbiology #noncodingRNAs #RNA #rnalocalization #RNAsplicing #ScienceJobs #hiring #research
https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/?fsp_sid=6444
This study shows that RNA splicing is widely dysregulated in FMRP-deficient mouse tissues and cells and involves multiple splicing factors, including MBNL1. In FMRP-depleted cells, Mbnl1 RNA is mis-spliced, resulting in improper cytoplasmic localization of MBNL1, which in turn causes impairment of further RNAs.
Nouveau labo!
Je cherche des étudiant(e)s aux cycles supérieurs voulant travailler dans le domaine de l'épissage de l'ARN en #cancer et #immunologie.
New lab!
I'm looking for grad students interested in #RNAsplicing in #cancer and #immunology
Nous examinons les variations de l’ARN pour trouver de nouveaux traitments contre le cancer Notre labo utilise des données de séquençage à haut débit et des validations expérimentales pour trouver des variations de l’ARN impliquées dans le développement de tissus normaux et des cancers. En étudiant les variations d’épissage de l’ARN, il est possible de découvrir des signatures moléculaires ignorées par d’autres approches. Au cours des dernières années, l’analyse du transcriptome a permis d’apporter une lumière nouvelle sur des questions fondamentales dans les domaines des troubles du spectre de l’autisme et du cancer.
This study explores the transformation of hematopoietic stem cells into full-blown acute myeloid leukemia by analyzing the transcriptomes of 18,900 pre-leukemic and leukemic cells at different stages. This emphasizes the critical roles of RNA splicing, including a novel tumor specific alternative splicing event in Tmem134, in the emergence and maintenance of leukemia.
This study explores the transformation of hematopoietic stem cells into full-blown acute myeloid leukemia by analyzing the transcriptomes of 18,900 pre-leukemic and leukemic cells at different stages. This emphasizes the critical roles of RNA splicing, including a novel tumor specific alternative splicing event in Tmem134, in the emergence and maintenance of leukemia.
This study explores the transformation of hematopoietic stem cells into full-blown acute myeloid leukemia by analyzing the transcriptomes of 18,900 pre-leukemic and leukemic cells at different stages. This emphasizes the critical roles of RNA splicing, including a novel tumor specific alternative splicing event in Tmem134, in the emergence and maintenance of leukemia.
Referenced link: https://medicalxpress.com/news/2023-03-blood-stem-cells-rna-splicing.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-blood-stem-cells-rna-splicing.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1638204839007080452#m
RT by @physorg_com: What makes blood stem cells transform? Regulation of #RNAsplicing may be an answer @MolecularCell https://linkinghub.elsevier.com/retrieve/pii/S109727652300151X https://medicalxpress.com/news/2023-03-blood-stem-cells-rna-splicing.html
Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome (MDS) patients. In a study published in the journal Molecular Cell, they explain what makes hematopoietic stem cells acquire malignant traits in cancer.
'Gene duplication and diversification allow hosts to mutate otherwise essential genes, whereas changes in transcriptional regulation can selectively activate genes should their constitutive expression be detrimental. To counter mutational tolerance, it has been suggested that viruses target essential genes as host cofactors, because the genes are less prone to variability'
#Virology #HostPathogen #RNASplicing
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001934
jobRxiv
PLOS Biology
Mathieu Quesnel-Vallières
Phys.org
Thiago Carvalho