We need to talk about David J. Brenner (the far-UVC researcher)
Notes on studies from the far-UVC researcher most cited on social media, plus thoughts on influencers posting misinformation online
https://mathissweet.substack.com/p/we-need-to-talk-about-david-j-brenner
"Most posts promoting far-UVC cite DJB studies, sometimes exclusively
Whenever I’ve see someone talking about how far-UVC is safe, they have cited studies by David J. Brenner. Often exclusively.
Using the two first examples that came to mind, every far-UVC study or document referenced by both posts had DJB as an author. I have decided to anonymize these examples and not include screenshots, because the particulars of who posted these are not relevant to the overall point I’m trying to make.
The first example cited four far-UVC studies, all by DJB. The second example cited 3 far-UVC DJB studies, a far-UVC document DJB was an author on, and a review of germicidal UV that didn’t include anything about far-UVC. All three DJB studies cited by the second example post were also cited by the first example post (shared reference A, shared reference B, shared reference C, DJB reference unique to the first example post).
It’s important to note that if references are formatted in a certain (totally standard and correct) way, you cannot see whether or not it’s a DJB study. As an example, here are two ways to properly cite shared reference A, where only the second example includes his name:
• Buonanno, M. et al. Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses. Sci Rep 10, 10285 (2020). https://doi.org/10.1038/s41598-020-67211-2
• Buonanno, M., Welch, D., Shuryak, I., Brenner, DJ.. Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses. Sci Rep 10, 10285 (2020). https://doi.org/10.1038/s41598-020-67211-2
One slide from the second example post referred to a result from shared reference B, where DJB and co-authors stated, “At a room ventilation rate of 3 air-changes-per-hour (ACH), with 5 filtered-sources the steady-state pathogen load was reduced by 98.4% providing an additional 184 equivalent air changes (eACH).“ The poster added on that this was over ten times more effective than air purifiers. There are a number of problems with these statements, including:
• Lack of details regarding the findings and experimental details, the most glaring of which is described in the next point.
• The results around reducing the concentration of live aerosolized pathogens by 98.4 % are under experimental conditions where the far-UVC dose exceeded the maximum daily limit for safe exposure outlined by the International Commission on Non-Ionising Radiation Protection (ICNIRP). I would suspect that most viewers of this post would not assume they were reporting results for UV doses that exceeded maximum daily exposure safety limits.
• The statement about this (unsafely high dose) of far-UVC being over ten times more effective than air purifiers lacks so much information that it cannot be assessed for truth.
• These results are also based on the bacterium being suspended in water (the most simple protein-free liquid possible) prior to being aerosolized–more realistic aerosol compositions would shield the bacteria from far-UVC exposure and result in lower inactivation rates than 98.4 % (see near the end of my previous post entitled “Safety concerns around far-UVC radiation: Poking holes in the premises of the claim “far-UVC is safe for more details about this point).
DJB and co-authors rarely call far-UVC radiation safe, usually instead calling it potentially safe. As well, these three studies do not work with humans, animals, human cells nor animal cells, and therefore are not even studies attempting to evaluate safety (despite the title of shared reference A, present in the reference examples earlier). Thus, when people on social media cite these studies to provide evidence that far-UVC radiation is safe, I believe they are both misrepresenting the studies and citing studies which don’t provide evidence for their claims.
Methodological issues and misleading results
There is what appears to be an inherent contradiction in some of the DJB studies, that again, I touched on in my previous far-UVC post. That being: DJB and co-authors explain that far-UVC radiation is potentially safe due to proteins in the dead skin layer (the stratum corneum or SC) and proteins in the tears absorbing the UV radiation, and yet, they don’t include real-world levels of proteins, glycoproteins, etc. in the aerosols they generate to test how effective far-UVC is at inactivating airborne pathogens. To quote shared reference A:
“In short (see below) the reason is that far-UVC light has a range in biological materials of less than a few micrometers, and thus it cannot reach living human cells in the skin or eyes, being absorbed in the skin stratum corneum or the ocular tear layer. But because viruses (and bacteria) are extremely small, far-UVC light can still penetrate and kill them.“
A few things come to mind from reading this (see references for these points and more info in my previous far-UVC post):
• When airborne pathogens are exhaled by someone, they are present in aerosols and larger respiratory droplets, which contain proteins and glycoproteins from where they originated, like from sputum, mucus or saliva. Importantly, some of these larger respiratory droplets are much larger in diameter than a few micrometers.
• What about people with thinner stratum corneums (SCs), skin on the body that lacks an SC, regions on the body with thinner SCs, people with insufficient tear production, etc.?
• What about other parts of the body that can be exposed to far-UVC that lack an SC, like many parts of the inside of the mouth?
As well, DJB studies usually look for DNA damage in the form of pyrimidine dimers, and less often look for a marker associated with double-stranded DNA breaks. To quote a DJB study from 2015, speaking about a different kind of radiation that can also cause double-stranded DNA breaks, “Ionizing radiation exposure is a risk factor for cancer in humans [6]. Ionizing radiation exposure can induce DNA double-strand breaks (the most deleterious genetic lesions), which, in turn, can trigger several detrimental cellular responses including carcinogenesis [7].“ Importantly, a study by another group reports that far-UVC produced more double-stranded DNA breaks in living human cells (without an SC layer or tears) and less pyrimidine dimers than other non-far-UVC lamps (again, this is touched on in my previous far-UVC post). Based on that study, it appears that looking for DNA damage in the form of double-stranded breaks instead of pyrimidine dimers may be more applicable when it comes to far-UVC radiation, especially when we consider the higher cancer risk from these double-stranded breaks compared to pyrimidine dimers.
What I think is the most important takeaway/application of this information, and general thoughts about influencers posting misinformation around precautions online
I feel strongly that these points should be addressed publicly by influencers/organizations that promote far-UVC by citing DJB studies. I think this information must be acknowledged if they want to promote anything remotely resembling being in favour of informed consent when it comes to exposure to ultraviolet radiation. And I think it would be dishonest and deceptive to ignore the information in this post if you promote far-UVC tech. I acknowledge that they might not be aware of this information, and that is a huge part of the problem that I personally find inexcusable.
The two example posts discussed at the beginning of this post were published in 2023 or later. Both posts cited the two studies, published in 2018 and 2020, whose competing interest sections were updated in September 2021. As I showed earlier, these updates are clearly explained and present in the updated versions of the studies themselves. If these studies were read and reviewed after September 2021 during the making of these posts, the creators of these posts failed to notice and/or comment on the fact that the competing interest sections were incomplete when the papers were submitted and initially published.
I would like to stress that I strongly believe that thorough, in-depth, critical review of studies should be performed to ensure the safety and effectiveness of any airborne infectious disease precautions you are recommending, renting out and/or selling. If you are unable or unwilling to do that, it is my opinion that you should not post about precautions that don’t have strong evidence like ventilation, air purification and well-fitting high-quality respirators without a lot of wear time and without a lot of dons/doffs. I think to not do so is irresponsible to the point of being dangerous, depending on the questionable precaution.
I have heard from people I know personally as well as internet strangers who claim they lowered their effective precautions like respirators and swapped them for nasal sprays, due to nasal spray misinformation they saw online. I wonder how many people have developed Long COVID from swapping respirators for nasal sprays. When it comes to folks recommending you wear the same respirator for 40 hours (see my post entitled “Debunking the myth that N95s are super protective for 40 hours of wear (let’s stop recommending it!)” for more info), someone who was told that misinformation over and over told me that they got COVID-19 while wearing their respirators for about 30 hours each. They think that extended wear of each respirator could have been part of how they caught COVID-19, and after their acute infection they developed Long COVID."
#MaskUp #WearAMask #CovidRealist #CovidIsAirbone #LongCovid #YallMasking #DisabledLiberation #DisabilityJustice
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