🧠 “Correlation ≠ causation”? This new study put it to the test: activity in posterior parietal #cortex not only correlates with navigation choices, it is causal. Using a #BrainMachineInterface, mice could steer solely from these signals.
🌍 https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00633-3
#Neuroscience #SystemsNeuro #Causality #DecisionMaking #BMI #correlation
» #neuroscience has become so broad & technically sophisticated that individual researchers can no longer fully understand the technical foundations of their experiments.
The average #systemsneuroscience project, for example, requires in-depth knowledge of animal #surgery #mechanical #optical & #electrical #engineering #statistics and #computerscience «
@knutson_brain @beneuroscience @PessoaBrain @axoaxonic @debivort @NicoleCRust @MolemanPeter @DrYohanJohn
Not #systemsneuro but #systemsbiology
#NickLane
top-down middle-down
organism to cell:
» quite strong argument is the other way around, metabolism comes first, quite spontaneous
…
fairly controversial still, work from 10y «
Happy & proud to share our latest work with the #bluespot community, #locuscoeruleus enthusiasts, and anyone else willing to read 😉
https://www.biorxiv.org/content/10.1101/2023.10.16.562534v1
4 years ago, we had the idea that endogenous neuromodulatory systems are in place that control LC activity, thereby promoting adaptive behavioral responses in challenging environments.
We examined the role of Neuropeptide Y, as a possible candidate system for this, and identified a new population of #NPY-expressing neurons, distributed in the pericoerulean space.
We showed that peri-LC NPY cells innervate the region, providing #NPY input onto #noradrenergic neurons of the LC, and strongly inhibiting their activity, via Y1Rs.
Next, we showed that chemogenetic stimulation of NPY cells led to anxiety-relief, via Y1Rs, and conversely, inhibition of NPY neurons triggered an anxiogenic phenotype.
Together, we showed a novel role for NPY-mediated #neuromodulation of the LC in adaptive behaviors.
We re happy to hear your thoughts /ideas /feedback on our data.
Please share/boost. Happy reading 🔵
An especially cool new paper in @PLOSBiology, on spatial navigation in goldfish and the role(s) of a somewhat unique cell type in the goldfish brain. The cells are a kind of boundary vector cell, that respond when the animal is moving away from a boundary. Really interesting experimental design, fun paper to read.
Now the subject of a great little piece in the #nytimes!
https://www.nytimes.com/2023/04/25/science/goldfish-brain-computer-navigation.html
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001747
TIL @MolemanPeter blog:
Enjoyed reading first two of such clearly written short posts style, and with handful complementary key references!
» I do believe in how I fill in the gaps in my knowledge «
https://breininactie.com/who-is-a-believer/
» Every human trait is heritable as well as acquired «
https://breininactie.com/obesity-heritability/
#neuroscience
#complexSystems
#systemsNeuro
#neuroTheory
#neuroBlog
#neurodon
Another not-to-be-missed talk from the WWN series, tomorrow @ 5pm CET
Cagla Eroglu | How do Astrocytes Sculpt Synaptic Circuits?
https://www.world-wide.org/seminar/8674/
Another cool seminar from WWN tomorrow (4pm NL time), tune in!
Dr. Nadine Gogolla | Two sides of emotion expressions: readouts and regulators
https://www.world-wide.org/seminar/8778/
Lateral hypothalamus, vPAG, leptin, high fat diet, binge, early life stress... this paper has it all! #stressfeeding #systemsneuro #circuits
Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus–brainstem pathway | Nature Neuroscience
https://www.nature.com/articles/s41593-022-01208-0
Early-life trauma is a risk factor for binge eating and obesity later in life. Shin et al. identify a hypothalamus–brainstem circuit in mice that underlies the early-life trauma-induced binge-like consumption of high-fat diet and obesity-prone characteristics.
Is there anything the #LC can't do.?
“...activation of LC NEergic signaling during CFC memory encoding mediates engram early tagging in the mPFC and systems consolidation of remote memory“
Noradrenergic signaling mediates cortical early tagging and storage of remote memory | Nature Communications
https://www.nature.com/articles/s41467-022-35342-x
The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are critical for remote memory storage.
Fabrizio Musacchio
Teixi
Danai Riga
Stephen Matheson🌵🌲
Danai Riga
