Happy & proud to share our latest work with the #bluespot community, #locuscoeruleus enthusiasts, and anyone else willing to read 😉

https://www.biorxiv.org/content/10.1101/2023.10.16.562534v1

4 years ago, we had the idea that endogenous neuromodulatory systems are in place that control LC activity, thereby promoting adaptive behavioral responses in challenging environments.

We examined the role of Neuropeptide Y, as a possible candidate system for this, and identified a new population of #NPY-expressing neurons, distributed in the pericoerulean space.

We showed that peri-LC NPY cells innervate the region, providing #NPY input onto #noradrenergic neurons of the LC, and strongly inhibiting their activity, via Y1Rs.

Next, we showed that chemogenetic stimulation of NPY cells led to anxiety-relief, via Y1Rs, and conversely, inhibition of NPY neurons triggered an anxiogenic phenotype.

Together, we showed a novel role for NPY-mediated #neuromodulation of the LC in adaptive behaviors.

We re happy to hear your thoughts /ideas /feedback on our data.

Please share/boost. Happy reading 🔵

#preprint #neuroscience #systemsneuro #ephys #stress

This is intriguing. I struggle with both sleep quality and memory. I'll definitely be doing some further reading about the #LocusCoeruleus.

Neuroscience News: Brain's Blue Spot, Locus Coeruleus, Is A Key Player in Sleep Quality and Memory
https://neurosciencenews.com/locus-coeruleus-memory-sleep-23965/

@neuroscience

Postdoc position in locus coeruleus connectomics of resilience at MGH

Massachusetts General Hospital / Harvard Medical School

Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!

See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=57015

Postdoc position in locus coeruleus connectomics of resilience at MGH

Massachusetts General Hospital / Harvard Medical School

Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!

See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=53370

Postdoc position in locus coeruleus connectomics of resilience at MGH

Massachusetts General Hospital / Harvard Medical School

Exciting postdoc on #locuscoeruleus functional networks project in #Alzheimers in #Boston? Come join our fun, collaborative lab at MGH!

See the full job description on jobRxiv: https://jobrxiv.org/j...
https://jobrxiv.org/job/massachusetts-general-hospital-harvard-medical-school-27778-postdoc-position-in-locus-coeruleus-connectomics-of-resilience-at-mgh/?feed_id=52961

Plugging here for fellow #bluespot member & #locuscoeruleus enthusiast, Greyson Sipe:

"the Sipe lab officially started at Penn State in March, 2023 and we are actively recruiting graduate students and postdoctoral fellows! Please feel free to spread the news to anybody interested in studying neurons, astrocytes, and neuromodulators in arousal, stress and addiction. The lab is pretty much set up with a cutting-edge 2-photon microscope, a custom 1-photon widefield scope, two dual-color fiber photometry rigs, and a suite of behavioral rigs with optogenetics (mini-scopes are on the way)".

For inquiries check:
https://www.sipelab.com/openings

New instance, new #introduction!
I am a psychologist, turned behavioral neuroscientist, turned electrophysiologist. Finishing my postdoc @ https://meyelab.net/ and soon to start @ http://mcn.cncr.nl/ NL

I am interested in all things #circuits, #patching, #stress and the incredible #locuscoeruleus

You ll find me knitting, baking & complaining, most times, simultaneously.

Looking forward to meet, listen & learn.