Reddit Tech VN Bot"Kết quả dự đoán cấu trúc protein phức hợp đối xứng có thể mở rộng. Công cụ Cosmohedra giúp dự đoán cấu trúc protein lớn với độ chính xác cao, tốc độ nhanh và tiết kiệm tài nguyên. #CấuTrúcProtein #DựĐoánProtein #CôngNghệSinhHọc #ProteinComplex #StructurePrediction #BioTechnology #SinhHọc #KhoaHọc"
michael6-Mar-2025
A new algorithm sheds light on ‘disordered’ #proteins
The #IntrinsicallyDisorderedProteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making #structurePrediction particularly challenging. These proteins although exhibit chaotic and ‘disordered’ structures, they still perform essential functions.
https://www.eurekalert.org/news-releases/1075837 #science
A new algorithm sheds light on ‘disordered’ proteins
Researchers from the Biomedical Sciences Research Center “Alexander Fleming” and the Centre for Misfolding Diseases at the University of Cambridge have found a way to predict the structure of a significant fraction of the proteome that was previously considered “dark” and difficult to be studied
MCDuncanLabI use Alphafold (actually colabfold) and am happy to answer questions, but I'm just a user. There are people with more expertise than me here.
Hashtags might find the right people
#StructurePrediction #alphafold #alphafold2 #colabfold #ProteinStructure #StructuralBiology #ProteinPrediction #protein #bioinformatics
katch wreck"The designs for all eight of the predicted novel αβ-folds with a four-stranded β-sheet, including a knot-forming one, folded into #structures close to the design models. Further, the rules predicted more than 10,000 novel αβ-folds with five- to eight-stranded β-sheets; this number far exceeds the number of αβ-folds observed in #nature so far."
https://www.nature.com/articles/s41594-023-01029-0
#protein #folding #proteinFolding #structuralBiology #structurePrediction
Exploration of novel αβ-protein folds through de novo design - Nature Structural & Molecular Biology
Here the authors carry out a systematic de novo protein design exploration of novel αβ-folds predicted under a defined set of rules for β-sheet topology, in an effort to find out the extent to which all possible αβ-folds are already sampled in nature.
Jinwoo LeemResearch Topics of interest:
* Protein #structureprediction - #antibodies and TCRs
* #NLP and #languages in general. E.g., there are many Korean expressions that I wish I could say in English and vice-versa, and I wonder if LLMs will ever "know" the frustration! (Meta: thinking about this makes me 답답해)
* Few/zero shot learning, self supervision
* repertoire scale #NGS analyses