Mastodawn

Mechanism of co-transcriptional cap snatching by #influenza #polymerase, https://etidiohnew.blogspot.com/2026/03/mechanism-of-co-transcriptional-cap.html

Mechanism of co-transcriptional cap snatching by #influenza #polymerase

Hacker News Feb 27

Qt45: A small polymerase ribozyme that can synthesize itself

https://www.science.org/doi/10.1126/science.adt2760

#HackerNews #Qt45 #Polymerase #Ribozyme #Self-Synthesis #Science #News #Innovation

Giuseppe Michieli Jan 17

#Polymerase #mutations underlie early #adaptation of #H5N1 #influenza virus to dairy #cattle and other #mammals, https://etidiohnew.blogspot.com/2026/01/polymerase-mutations-underlie-early.html

#Polymerase #mutations underlie early #adaptation of #H5N1 #influenza virus to dairy #cattle and other #mammals

Giuseppe Michieli Dec 20

Emergence of #mammalian-adaptive #PB2 #mutations enhances #polymerase activity and #pathogenicity of #cattle-derived #H5N1 #influenza A virus, https://etidiohnew.blogspot.com/2025/12/emergence-of-mammalian-adaptive-pb2.html

Emergence of #mammalian-adaptive #PB2 #mutations enhances #polymerase activity and #pathogenicity of #cattle-derived #H5N1 #influenza A virus

Giuseppe Michieli Oct 28

An evolutionary approach to identify #mammalian adaptive #mutations in the avian #influenza #polymerase complex, https://etidiohnew.blogspot.com/2025/10/an-evolutionary-approach-to-identify.html

An evolutionary approach to identify #mammalian adaptive #mutations in the avian #influenza #polymerase complex

Giuseppe Michieli Aug 14, 2025

#Polymerase #mutations underlie early #adaptation of #H5N1 #influenza virus to dairy #cattle and other #mammals, https://etidiohnew.blogspot.com/2025/08/polymerase-mutations-underlie-early.html

#Polymerase #mutations underlie early #adaptation of #H5N1 #influenza virus to dairy #cattle and other #mammals.

Bose-Einstein-Kondensat Jun 10, 2025

A portable low-cost #Arduino-controlled #OpenSource #polymerase chain reaction device:

-4-well aluminum heating block
-heated lid
-heating/cooling rates: 1.78/1.52 °C/s
- temp. accuracy: ± 0.55 °C
-cost: US $120
-requires #MATLAB

https://doi.org/10.1016/j.ohx.2025.e00635
#DIYbio #lab #instruments #PCR #DNA

Giuseppe Michieli Jun 7, 2025

#Influenza A virus #polymerase co-opts distinct sets of host proteins for #RNA transcription or #replication, https://etidiohnew.blogspot.com/2025/06/influenza-virus-polymerase-co-opts.html

#Influenza A virus #polymerase co-opts distinct sets of host proteins for #RNA transcription or #replication

Giuseppe Michieli Jan 7, 2025

#Polymerase #mutations underlie #adaptation of #H5N1 #influenza virus to dairy #cattle and other #mammals. https://etidiohnew.blogspot.com/2025/01/polymerase-mutations-underlie.html

#Polymerase #mutations underlie #adaptation of #H5N1 #influenza virus to dairy #cattle and other #mammals.

Giuseppe Michieli Dec 10, 2024

#Replication #Restriction of #Influenza #H5N1 Clade 2.3.4.4b Viruses by #Human Immune Factor, 2023–24, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/31/1/24-1236_article

We show that human myxovirus resistance protein 1 (MxA) suppresses replication of influenza H5N1 viruses isolated from #mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral #polymerase complex components from a human-adapted MxA-resistant strain in vitro.

Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023–2024

HPAI A(H5N1) Clade 2.3.4.4b Viruses, 2023–2024

Emerging Infectious Diseases journal