Giuseppe MichieliEmergence of #mammalian-adaptive #PB2 #mutations enhances #polymerase activity and #pathogenicity of #cattle-derived #H5N1 #influenza A virus, https://etidiohnew.blogspot.com/2025/12/emergence-of-mammalian-adaptive-pb2.html
''Of the nine D1.1 #infections in #humans, three viruses acquired #PB2 #mammalian #adaptations: D701N in A/Nevada/10/2025 and E627K in A/Wyoming/01/2025 and A/British Columbia/PHL-2032/2024''
Evolutionary trajectories and #zoonotic #potential of a #PB2 #mutation triad (I147T, K339T, and A588T) in avian #influenza viruses, https://etidiohnew.blogspot.com/2025/12/evolutionary-trajectories-and-zoonotic.html
An emerging #PB2-627 #polymorphism increases the #zoonotic #risk of avian #influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts, https://etidiohnew.blogspot.com/2025/08/an-emerging-pb2-627-polymorphism.html
Glutamic Acid at Position 343 in #PB2 Contributes to the #Virulence of #H1N1 #Swine #Influenza Virus in Mice, https://etidiohnew.blogspot.com/2025/07/glutamic-acid-at-position-343-in-pb2.html
E627V #mutation in #PB2 protein promotes the #mammalian #adaptation of novel #H10N3 avian #influenza virus, https://etidiohnew.blogspot.com/2025/06/e627v-mutation-in-pb2-protein-promotes.html
Immediate #PB2-E627K amino acid #substitution after single #infection of highly pathogenic avian #influenza #H5N1 clade 2.3.4.4b in mice, https://etidiohnew.blogspot.com/2025/06/immediate-pb2-e627k-amino-acid.html
A rapid #review of the avian #influenza #PB2 #E627K #mutation in #human infection studies, https://etidiohnew.blogspot.com/2025/04/a-rapid-review-of-avian-influenza.html
Synergistic effects of PA (S184N) and #PB2 (E627K) #mutations on the increased pathogenicity of #H3N2 canine #influenza virus #infections in mice and #dogs, https://etidiohnew.blogspot.com/2025/04/synergistic-effects-of-pa-s184n-and-pb2.html
Cross-species and #mammal-to-mammal #transmission of clade 2.3.4.4b highly pathogenic avian #influenza A #H5N1 with #PB2 adaptations, https://etidiohnew.blogspot.com/2025/03/cross-species-and-mammal-to-mammal.html