As already indicated by previous experiments, not only #V_cholerae reacts to purified #peptidoglycan but this behaviour can also be observed in different biofilm-forming species.
So Sanika has "demonstrated that exogenous PG released by cellular lysis is a general danger signal to which several bacterial species respond by forming biofilms. The resulting biofilms serves as a refuge that protects against phage predation or other biotic and abiotic stresses that can lyse bacterial cells."
The septal peptidoglycan hydrolysis machinery is a crucial structure for bacterial cell division. This study analyses the cryo-EM structure and enzymatic function of E. coli FtsEX, with and without the lytic-factor protein EnvC, characterizing the molecular basis of FtsEX regulation of peptidoglycan hydrolysis, which could be used to develop novel treatments targeting drug-resistant bacteria.
x-posting from twitter...
https://twitter.com/Dr_Lori_Burrows/status/1649421714822950913?s=20
...not Streptomyces, it's a #peptidoglycan biosynthesis mutant of #Pseudomonas aeruginosa. I feel like we still know very little about this crazy #superbug. We took this SEM image 10 years ago and I've been scratching my head over it ever since.
#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1.
How to resist a #phage ...
This fascinating new research explores how Gram positive #bacteria (Listeria monocytogenes) can escape #bacteriophage infection by enzymatic degradation of their own bacterial cell wall #peptidoglycan to form a transient and reversible cell-wall deficient L-form removing cell wall targets used by the phage for attachment.
Learn more in this new paper in Nature Microbiology on:
#Microbiota-induced active translocation of #peptidoglycan across the intestinal barrier dictates its within-host dissemination | PNAS
#Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen #Agrobacterium tumefaciens | Nature Communications
Some bacteria use the muropeptide transporter AmpG for uptake and recycling of cell wall fragments that are released during cell growth and division. Here, Gilmore & Cava show that the plant pathogen Agrobacterium tumefaciens, which lacks an AmpG homologue, uses a different type of transporter for the same function, which is essential for normal growth in this organism.
#Peptidoglycan recycling mediated by an ABC transporter in the plant #pathogen #Agrobacterium tumefaciens | Nature Communications
Some bacteria use the muropeptide transporter AmpG for uptake and recycling of cell wall fragments that are released during cell growth and division. Here, Gilmore & Cava show that the plant pathogen Agrobacterium tumefaciens, which lacks an AmpG homologue, uses a different type of transporter for the same function, which is essential for normal growth in this organism.
PLOS Biology
Eric Jelli
Small Things Considered
The EMBO Journal
Professor Mark Osborn
Vivek Mutalik