
Impact of Nutritional Therapy during Intensive Care Unit Admission on Post-Intensive Care Syndrome in Patients with COVID-19
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<h5 class="section-title" id="d11783436e448">Introduction</h5>
<p dir="auto" id="d11783436e450">Nutritional therapy is an important component of intensive care. We investigated the
associations of nutritional therapy in the acute phase of severe COVID-19 with the
long-term outcomes of post-intensive care syndrome (PICS) and post-COVID-19 conditions.
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<h5 class="section-title" id="d11783436e453">Methods</h5>
<p dir="auto" id="d11783436e455">A questionnaire on the health status after COVID-19 was sent to patients 1 year after
infection and PICS was evaluated. Total energy and protein intakes during the first
week after admission to the intensive care unit (ICU) were calculated. The primary
endpoint was a decrease in quality of life (QOL) defined by EuroQol5-dimensions 5-level
(EQ5D5L) <0.8. A multivariable regression analysis was used to examine.
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<h5 class="section-title" id="d11783436e458">Results</h5>
<p dir="auto" id="d11783436e460">A total of 220 ICU patients were included in this study. Median total energy and protein
intakes were 65.1 kcal/kg/week and 3.3 g/kg/week, respectively. Total energy and protein
intakes were associated with EQ5D5L scores (energy: unit odds ratio 0.98 [0.97โ0.99],
<i>p</i> value <0.01; protein: unit odds ratio 0.72 [0.59โ0.87],
<i>p</i> value <0.01). Insufficient total energy and protein intakes were associated with
malaise, arthralgia, myalgia, palpitations, sleep disturbance, and muscle weakness.
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<h5 class="section-title" id="d11783436e469">Conclusions</h5>
<p dir="auto" id="d11783436e471">Poor nutrition during the first week after ICU admission was associated with a decreased
QOL 1 year after. These nutrition shortages were also associated with an increased
risk of developing PICS, post-COVID-19 conditions, which may contribute to decreased
QOL.
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