Mastodawn

(Glyco-)sphingolipids play important roles in bacterial infections. Studying them requires powerful chemical tools.

Jürgen Seibel talked at #Biochemistry2026 about the synthesis of probes based on (glyco-)sphingolipids and their use to study biology e.g. using expansion microscopy.

https://www.nature.com/articles/s41467-024-51874-w
#Biochemistry #Chemistry #LipidTime #GlycoTime #probes #infections

GDCh Division of Biochemistry 2d ago

Interesting talk by Jürgen Seibel at #Biochemistry2026. He talked about "Enzyme and Substrate Engineering for novel CAZymes activities".

#Biochemistry #Chemistry #ChemBio #Glycotime #Lipidtime

Stephan Hacker Dec 3

Great talk by Floor Stevens from the group of Mario van der Stelt of our @LED3hub at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

Stephan Hacker Dec 3

Great talk by Floor Stevens from the group of @[email protected] of our @[email protected] at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2". #Chemistry #ChemBio #LipidTime #Glycotime

Show thread

Stephan Hacker Nov 25

She also talked about the formation of coacervates based on #DNA or #RNA as well as #peptides and their potential involvement in early life. (2/2) www.nature.com/articles/s41... #ChemSky #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

Differential stability and dyn...

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry - Nature Communications

Mixtures of peptides and nucleic acids tend to demix and form coacervate droplets. Here, the authors show that even short peptides and oligonucleotides form droplets. DNA and RNA impart different properties to these protocells – stability, fluidity and the potential to host RNA chemistry.

Nature

Stephan Hacker Nov 25

How did primitive membranes form at the #OriginOfLife and how did they evolve into the cellular envelopes of modern cells?

Exciting talk by Claudia Bonfio about the non-enzymatic formation of phospholipids under conditions that are plausible for early Earth. https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc05362a (1/2)

#Chemistry #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids