Investigation of Esketamine Administration During Surgical Procedures for the Alleviation of Postoperative Anxiety and Depression in Adolescent Patients: A Randomized Controlled Trial (Li, et al, 2026) https://pubmed.ncbi.nlm.nih.gov/42261442/ Subanesthetic-dose esketamine during surgery effectively reduces postoperative anxiety and partially alleviates depressive symptoms in adolescents with acceptable safety. #esketamine #ketamine #depression #anxiety #mentalhealth #ketaminesafety

Association of Esketamine use with mortality and clinical outcomes in patients with cancer-related depression: A target trial emulation (Chen, et al, 2026) “esketamine was associated with lower mortality and generally comparable safety outcomes in CRD, supporting its role as a potential therapeutic option for managing CRD.” https://pubmed.ncbi.nlm.nih.gov/42235877/ #esketamine #psychedelics #cancer #depression #ketaminesafety #mentalhealth

https://pubmed.ncbi.nlm.nih.gov/42177858/ Ketamine-based ICU sedation and patient-centered outcomes: A systematic review and meta-analysis of mechanical ventilation duration, ICU length of stay, and delirium (Patel, et al, 2026) “These results support consideration of #ketamine as an adjunct in multimodal ICU sedation strategies” #ketaminesafety #icu #psychedelics

Retrospective Chart Review Evaluating Efficacy and Tolerability of Ketamine Continuous Infusion for Cancer-Related Pain (Atayee, 2026) https://pubmed.ncbi.nlm.nih.gov/42132553/ Ketamine Continuous infusion produced a statistically significant and clinically meaningful reduction in cancer pain that increased over the course of infusion and was tolerated without identified psychoactive or circulatory adverse events. #ketamine #cancer #painmanagement #oncology #psychedelics #ketaminetherapy #ketaminesafety

Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap
(Sezerano, et al, 2026) includes #ketamine and #cognitivebehavioraltherapy for #painmanagement https://pubmed.ncbi.nlm.nih.gov/42017149/ #ketaminesafety #ketaminetherapy

https://pubmed.ncbi.nlm.nih.gov/41989186/ Ketamine Use in Critically Ill Patients: Insights into Depressive Symptoms and Hemodynamic Changes (Patel, et al, 2026) “Subanesthetic ketamine improved specific depressive symptoms in critically ill ICU patients without significant hemodynamic instability. These findings support its potential as a rapid-acting antidepressant in the ICU, warranting further prospective trials.” #ketamine #ketaminesafety #icu #mentalhealth

https://psychedelicmentalhealth.net/ketamina-en-cirugia-cardiaca-una-revision-sistematica-y-un-meta-analisis-de-efectos-sobre-marcadores-inflamatorios-y-resultados-clinicos-ferreira-de-lima-e-souza-et-al-2025/ The psychedelic medicine, ketamine, which has been used in anesthesia, pain management, mental health, and palliative care was given to cardiac patients with no change in health outcomes from adverse effects of ketamine studied for its safety and efficacy in a number of on label and off-label indications. Context for #ketaminesafety for much lower doses in mental health, when administered by mouth, to non-cardiac patients who have been medically screened in advance.

https://psychedelicmentalhealth.net/spotlight-real-world-clinical-data-on-the-long-term-effectiveness-and-safety-of-generic-racemic-ketamine-treatment-massaneda-tuneu-et-al-2025/ Spotlight: Real-world clinical data on the long-term effectiveness and safety of generic racemic ketamine treatment (Massaneda-Tuneu, et al, 2025)
"...the real-world clinical data presented here suggest a sustained effectiveness and safety profile of longer-term ketamine treatment for up to 6 months for patients with TRD. " #ketamine #ketaminesafety #ketaminetherapy #psychedelics #psychedelicresearch #mentalhealth #depression

https://psychedelicmentalhealth.net/spotlight-from-anesthetic-to-neuroprotector-multi-omics-reveals-ketamines-previously-unexplored-neuroprotective-role-in-alzheimers-disease-gong-et-al-2025/ Spotlight- From Anesthetic to Neuroprotector: Multi-Omics Reveals Ketamine's Previously Unexplored Neuroprotective Role in Alzheimer's Disease (Gong, et al, 2025) This integrative study identifies robust diagnostic biomarkers and nominates ketamine for repurposing in AD. Experimental validation of ketamine's neuroprotective effects and FIBP's role is warranted. #ketamine #alzheimer #brains #neuroscience #psychedelicresearch #ketaminetherapy #ketaminesafety #psychedelics

https://psychedelicmentalhealth.net/spotlight-real-world-effectiveness-of-maintenance-ketamine-infusions-for-treatment-resistant-depression-in-major-depressive-disorder-and-bipolar-disorder-haikazian-et-al-2025/ Spotlight: Real world effectiveness of maintenance ketamine infusions for treatment-resistant depression in major depressive disorder and bipolar disorder (Haikazian, et al, 2025) "Ketamine was determined to be relatively safe, with zero cases of suicidal behaviour and addiction behaviour throughout treatment." #ketamine #ivketamine #ketaminetherapy #bipolar #depression #mentalhealth #psychedelics #psychedelicresearch #ketaminesafety