https://psychedelicmentalhealth.net/ketamina-en-cirugia-cardiaca-una-revision-sistematica-y-un-meta-analisis-de-efectos-sobre-marcadores-inflamatorios-y-resultados-clinicos-ferreira-de-lima-e-souza-et-al-2025/ The psychedelic medicine, ketamine, which has been used in anesthesia, pain management, mental health, and palliative care was given to cardiac patients with no change in health outcomes from adverse effects of ketamine studied for its safety and efficacy in a number of on label and off-label indications. Context for
#ketaminesafety for much lower doses in mental health, when administered by mouth, to non-cardiac patients who have been medically screened in advance.
Ketamina en Cirugía Cardíaca: Una Revisión Sistemática y un Meta-Análisis de Efectos sobre Marcadores Inflamatorios y Resultados Clínicos (Ferreira de Lima E Souza, et al, 2025)
La medicina psicodélica ketamina, utilizada desde hace décadas en anestesia, manejo del dolor, salud mental y cuidados paliativos, ha sido administrada en pacientes cardíacos sin observarse cambios negativos en los resultados clínicos atribuibles a efectos adversos del fármaco.
https://psychedelicmentalhealth.net/spotlight-real-world-clinical-data-on-the-long-term-effectiveness-and-safety-of-generic-racemic-ketamine-treatment-massaneda-tuneu-et-al-2025/ Spotlight: Real-world clinical data on the long-term effectiveness and safety of generic racemic ketamine treatment (Massaneda-Tuneu, et al, 2025)
"...the real-world clinical data presented here suggest a sustained effectiveness and safety profile of longer-term ketamine treatment for up to 6 months for patients with TRD. "
#ketamine #ketaminesafety #ketaminetherapy #psychedelics #psychedelicresearch #mentalhealth #depression https://psychedelicmentalhealth.net/spotlight-from-anesthetic-to-neuroprotector-multi-omics-reveals-ketamines-previously-unexplored-neuroprotective-role-in-alzheimers-disease-gong-et-al-2025/ Spotlight- From Anesthetic to Neuroprotector: Multi-Omics Reveals Ketamine's Previously Unexplored Neuroprotective Role in Alzheimer's Disease (Gong, et al, 2025) This integrative study identifies robust diagnostic biomarkers and nominates ketamine for repurposing in AD. Experimental validation of ketamine's neuroprotective effects and FIBP's role is warranted.
#ketamine #alzheimer #brains #neuroscience #psychedelicresearch #ketaminetherapy #ketaminesafety #psychedelics Spotlight: From Anesthetic to Neuroprotector: Multi-Omics Reveals Ketamine's Previously Unexplored Neuroprotective Role in Alzheimer's Disease (Gong, et al, 2025)
"This integrative study identifies robust diagnostic biomarkers and nominates ketamine for repurposing in AD. Experimental validation of ketamine's neuroprotective effects and FIBP's role is warranted."
Spotlight: Real world effectiveness of maintenance ketamine infusions for treatment-resistant depression in major depressive disorder and bipolar disorder (Haikazian, et al, 2025)
"Ketamine was determined to be relatively safe, with zero cases of suicidal behaviour and addiction behaviour throughout treatment."
Intravenous Ketamine Treatment for Depression: One-year Retrospective Study from a Tertiary Care Psychiatry Center from India - PubMed
The finding of this study indicates that ketamine infusion therapy is safe and effective as a rapidly acting adjunct treatment for depression.
Effects of Subanesthetic Intravenous Ketamine Infusion on Stress Hormones and Synaptic Density in Rats with Mild Closed-Head Injury - PubMed
<span><b>Background:</b> Every year, over 40 million people sustain mild traumatic brain injury (mTBI) which affects the glucocorticoid stress pathway and synaptic plasticity. Ketamine, a multimodal dissociative anesthetic, modulates the stress pathway and synaptic plasticity. However, the effects of post</span> …
A Comparison of Ketamine to Midazolam for the Management of Acute Behavioral Disturbance in the Out-of-Hospital Setting - PubMed
https://flip.it/EuhdzH Una comparación de la ketamina con el midazolam para el manejo de los trastornos agudos del comportamiento en el entorno fuera del hospital
#ketamine #ketamina #psychedelic #psychedelics #emergencymedicine #psychedelic #psychiatry #neuroscience #mentalhealth #nursing #behavioralhealth #spravato #psychedelicresearch #research #ketaminesafetyA Comparison of Ketamine to Midazolam for the Management of Acute Behavioral Disturbance in the Out-of-Hospital Setting - PubMed
In this cohort study of patients with acute behavioral disturbance, emergent airway support and other outcomes did not differ following out-of-hospital treatment with midazolam or ketamine.
https://link.springer.com/article/10.1007/s40263-025-01180-w Impact of Medical Comorbidities on Ketamine and Esketamine Treatment Effectiveness for Posttraumatic Stress Disorder and Depression: A Clinical Outcomes Analysis from the VA San Diego Healthcare System (Zhang, et al, 2025)
#ketamine found effective for
#depression and
#ptsd and safe to administer repeatedly even for those with traumatic brain injuries and obstructive sleep apnea
#mentalhealth #ketaminetherapy #psychedelic #psychedelics #psychedelictherapy #ketaminesafety 
Impact of Medical Comorbidities on Ketamine and Esketamine Treatment Effectiveness for Posttraumatic Stress Disorder and Depression: A Clinical Outcomes Analysis from the VA San Diego Healthcare System - CNS Drugs
Background Ketamine and esketamine are increasingly used to manage treatment-resistant depression and have also been shown to reduce symptoms of posttraumatic stress disorder (PTSD). Little is known about how common comorbidities in the veteran population, such as traumatic brain injury (TBI) or obstructive sleep apnea (OSA), may influence ketamine and esketamine treatment outcomes. Methods In this retrospective study, we analyzed clinical outcomes from Veterans Affairs (VA) San Diego Healthcare System’s ketamine program to assess the relationship between ketamine or esketamine treatment and changes in depression and PTSD symptoms, while also examining how common medical comorbidities influence treatment outcomes. We specifically examined whether a patient’s history of TBI or OSA would affect ketamine or esketamine treatment outcomes. Linear mixed-effects models were used to examine how TBI and OSA history interacted with ketamine/esketamine treatment to change PTSD Checklist for DSM-5 (PCL-5) and Patient Health Questionnaire-9 (PHQ-9) scores. Results This study included 119 veterans who received eight sessions of ketamine or esketamine treatment at the San Diego VA Medical Center. Using linear effects modeling, we found that repeated ketamine or esketamine sessions were significantly correlated with reductions in both depression (p < 0.005) and PTSD (p < 0.05) symptom scores. However, in veterans with comorbid TBI (n = 38) and severe OSA (n = 9), depression symptoms did not improve over the course of ketamine or esketamine treatment, suggesting this subgroup may require alternative treatments or OSA treatment prior to starting ketamine or esketamine treatment. Conclusions Ketamine and esketamine treatment did not improve symptoms of depression in veterans with comorbid TBI and severe OSA. Thus, our findings generally support ketamine and esketamine as effective interventions for depression and PTSD, while emphasizing the consideration of comorbidities such as OSA and TBI.
Chronic, combinatorial targeting of NMDARs and 5-HT4Rs exerts extended behavioral effects against stress-induced perseverative behavior and hyponeophagia (Chen, et al, 2025)
#ketamine #ketaminetherapy #psychedelic #psychedelics #psychedelicresearch #mentalhealth #ketaminesafety #drugsafety #neuroscienceToday you learned they give ketamine as part of anesthesia DURING OPEN HEART SURGERY
#ketamine #psychedelics #ketaminesafety #drugsafety Etomidate vs Ketamine-Propofol for Induction of Anesthesia in Coronary Artery Bypass Grafting: An Updated Systematic Review and Meta-Analysis (Kumar, et al 2025)
https://pubmed.ncbi.nlm.nih.gov/40221834/Etomidate vs Ketamine-Propofol for Induction of Anesthesia in Coronary Artery Bypass Grafting: An Updated Systematic Review and Meta-Analysis - PubMed
<span><b>Background:</b> Etomidate has minimal cardiovascular depressant effects at the cost of endogenous cortisol production suppression, whereas propofol has vasodilatory and myocardial depressant properties, which may be poorly tolerated in the cardiac surgical population. To offset the undesirable ef</span> …
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